|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In chronic airways disease patients, lung eosinophilia was associated with elevated MMP-12 levels, which was a predictor of emphysema.
|
30728205 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
MMP-12 is related to several diseases such as emphysema, myocardial infarction and liver fibrosis.
|
30880028 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, RV-induced IFN-γ stimulates MMP12 expression particularly in CD11b<sup>+</sup>/CD11c<sup>+</sup> macrophages, which may degrade alveolar walls thus leading to progression of emphysema in these mice.
|
30952808 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the basophil-derived IL-4/monocyte-derived IM/MMP-12 axis plays a crucial role in emphysema formation and therefore may be a potential target to slow down emphysema progression at the initiation phase of COPD.
|
30510003 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both the upregulation of PGF by MMP-12 and PGF downstream signaling molecules with pulmonary apoptosis and emphysema were also demonstrated in animals.
|
29722565 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings from experimental models suggest that some MMPs, such as MMP-12, may directly breakdown elastin, whereas others, particularly MMP-10 and MMP-28, promote the development of emphysema by influencing the proteolytic and inflammatory activities of macrophages.
|
29406250 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our findings define a novel physiological function of Shp2 in TGF-β1/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.
|
28814604 |
2017 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progressive airway wall remodelling and emphysema in pIgR(-/-) mice are associated with an altered lung microbiome, bacterial invasion of the airway epithelium, NF-κB activation, leukocyte infiltration and increased expression of matrix metalloproteinase-12 and neutrophil elastase.
|
27046438 |
2016 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
CTD_human |
A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.
|
25106431 |
2014 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that increased MMP12 and MMP1 expression may play a role in the pathogenesis of emphysema.
|
23900981 |
2014 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ITGB6-/- mice spontaneously develop age-related lung emphysema due to lack of ITGB6-TGF-β1 regulation of the MMP12 expression.
|
24043489 |
2013 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This finding supports a role for MMP-12 in the pathogenesis of COPD and might suggest that blocking MMP-12 activity in patients with COPD could prevent the further development of emphysema.
|
22305682 |
2012 |
|
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The rs652438 SNP alters MMP-12 activity with the A allele being more active, which is associated with increased macrophage infiltration and emphysema in the lungs of patients with COPD.
|
21730350 |
2011 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data demonstrate that cigarette smoke is a potent Th17 adjuvant and that IL-17RA signaling is required for chemokine expression necessary for MMP12 induction and tissue emphysema.
|
21647421 |
2011 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Macrophage elastase (also known as matrix metalloproteinase 12 or MMP12) is an enzyme predominantly expressed in mature tissue macrophages and is implicated in several disease processes, including emphysema.
|
19536155 |
2009 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MMP12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.
|
19706765 |
2009 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have uncovered a pathway in which the loss of integrin-mediated activation of latent TGF-beta causes age-dependent pulmonary emphysema through alterations of macrophage Mmp12 expression.
|
12634787 |
2003 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
CTD_human |
We have uncovered a pathway in which the loss of integrin-mediated activation of latent TGF-beta causes age-dependent pulmonary emphysema through alterations of macrophage Mmp12 expression.
|
12634787 |
2003 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema.
|
11875051 |
2002 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The following study examines the lung parenchyma of 23 patients with emphysema and 8 normal control samples for the expression of matrix matalloproteinase-1 (MMP-1), MMP-12, and MMP-9.
|
11254539 |
2001 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Macrophages from bronchoalveolar lavage fluid of 10 patients with emphysema and 10 normal volunteers were maintained in vitro for 24 h and assessed semiquantitatively for mRNA transcript levels of the matrix metalloproteinases (MMPs) gelatinases A and B, macrophage metalloelastase (MME), and interstitial collagenase.
|
9230755 |
1997 |