NCAM1, neural cell adhesion molecule 1, 4684

N. diseases: 445; N. variants: 34
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Furthermore, Ncam1 was highly expressed in leukemic progenitor cells in a murine leukemia model, and genetic depletion of <i>Ncam1</i> prolonged disease latency and significantly reduced leukemia-initiating cells upon serial transplantation. 30814062 2019
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Described for the first time in 1994 as CD4+ cutaneous lymphoma with high expression of CD56, BPDCN has been known previously with various names such as blastic natural killer (NK) leukemia/lymphoma, agranular CD4+ CD56+ hematodermic neoplasm, and agranular CD4+ NK cell leukemia. 29237977 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE CD56 expression in acute myeloid leukemia (AML) has been associated with extramedullary leukemia and multidrug resistance, but its clinical and prognostic significance has not been clearly identified. 16986129 2007
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE The combined overexpression of RUNX1 and NCAM during stress hematopoiesis in children with DS might be a key factor in the development of overt leukemia and/or in the growth advantage of the malignant GATA1s clone in ML- DS. 17043020 2006
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia. 14712486 2004
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE CD56 expression was analyzed in leukemic cells from 94 adults with primary AML in Taiwan and was correlated with clinical and hematologic features, cytogenetics, and immunophenotypes of the leukemia. 12189644 2002
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Standard MFC techniques were used to determine CD56 expression on the leukemia blasts cells. 12008081 2002
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE They showed two unusual features, including immunoreactivity for CD56 and a short-lived but rapidly progressive myelodysplastic phase preceding the appearance of frank leukemia. 11408070 2001
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma. 11401089 2001
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE This is an unusual case of CD56(+) aggressive lymphoma/leukemia characterized by the clonal expansion of two phenotypically different cell populations, variably balanced during the course of the disease. 10800166 2000
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE Because CD56 expression has been associated with both extramedullary leukemia and multidrug resistance, we sought to correlate CD56 expression with treatment outcome in AML with t(8;21). 9269784 1997
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 GeneticVariation disease BEFREE Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen--NCAM--CD3([G, D], E)--parallel--(ETS1, THY1)--11qter. 3248386 1988