NFATC2, nuclear factor of activated T cells 2, 4773

N. diseases: 154; N. variants: 22
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Taken together, these findings reveal a risk SNP-mediated long-range regulation on the NFATC2-ZFP90-BMP4 pathway underlying the initiation of CRC. 31641208 2020
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE We first found that NFATC2 is upregulated in primary CRC-SCs. 30410349 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for CRC as well as a therapeutic target, providing that upcoming studies confirm these results. 28504924 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE ASIC2 promotes metastasis of CRC cells by activating the calcineurin/NFAT1 pathway under acidosis and high expression of ASIC2 predicts poor outcomes of patients with CRC. 28927426 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Here, we used an experimental model of colitis-associated colorectal carcinoma to investigate the contribution of NFATc2 to the promotion of colonic tumors. 22738913 2012