LEF1, lymphoid enhancer binding factor 1, 51176

N. diseases: 211; N. variants: 13
Disease: Colonic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 AlteredExpression group BEFREE We found that Lef1 and Tcf1, but not Tcf3 and Tcf4, were upregulated at both mRNA and protein level with the formation of colon tumor in AOM-DSS mouse model. 27433921 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker group BEFREE Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblastic leukemia. 23325550 2013
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker group CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 AlteredExpression group LHGDN Wnt activation and alternative promoter repression of LEF1 in colon cancer. 16809766 2006