POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011 1992
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097 1987
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human The role of the parathyroid glands in adrenocorticotrophin-induced hypertension in the rat. 10513829 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Changes in pressor responsiveness do not explain ACTH hypertension. 3015460 1986
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat. 11518849 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Hormonal background of the hypertension and fluid derangements associated with adrenocorticotrophic hormone treatment of infants. 2551692 1989
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human In man ACTH produces systolic hypertension which can be reproduced by infusion of cortisol, but not deoxycorticosterone, at rates appropriate for conditions of ACTH stimulation. 3001556 1985
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Role of the renal medulla in adrenocorticotrophin-induced hypertension in rats. 1334993 1992
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Haemodynamic mechanisms of corticotropin (ACTH)-induced hypertension in the rat. 10658937 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat. 11703388 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human The role of this increased pressor responsiveness in ACTH/steroid-induced hypertension remains to be determined. 1321309 1992
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Analyses of aldosterone/PRA/cortisol 'day-curves' have revealed that (1) the hybrid gene dominates over wild type CYP11B2 in terms of aldosterone regulation and (2) correction of hypertension in FH-I requires only partial suppression of ACTH, and much smaller glucocorticoid doses than those previously recommended. 11595502 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Adrenocorticotrophin-induced hypertension in rats. Role of progesterone and digoxin-like substances. 8136112 1994
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 AlteredExpression group BEFREE Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity. 26103132 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Alterations in osmotic but not pressor responses to ACTH by optic recess lesions in sheep. 6279500 1982
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human We hypothesized that ACTH-induced hypertension in the rat is characterized by increased EPO production. 15110907 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Identifying the mechanism of ACTH-dependent proliferation of VSMCs may help to provide new therapeutic targets for hypertension. 29943847 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats. 1316127 1992
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 AlteredExpression group BEFREE In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. 28274841 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human However, when RAP is not allowed to rise, ACTH is associated with sodium retention and severe systemic hypertension, suggesting that the natriuretic effects of ACTH are caused by increased RAP and that the natriuresis blunts the chronic hypertensive effects of ACTH. 2849322 1988
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Therapeutic group CTD_human Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. 15554453 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. 11193135 2000