ROBO4, roundabout guidance receptor 4, 54538

N. diseases: 51; N. variants: 13
Disease: Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhibitor) blocked the Robo4 knockdown-mediated alteration in glioma angiogenesis in vitro. 25833462 2015
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE Short hairpin RNA targeting Robo4 also increased matrix metalloproteinase-9 (MMP-9) activity and expression in glioma cocultured ECs; pretreatment with the MMP inhibitor GM6001 partially blocked the effects of shRobo4 on the transendothelial electric resistance values and ZO-1 and occludin expression. 25470344 2015
CUI: C0017638
Disease: Glioma
Glioma 		0.030 AlteredExpression disease BEFREE The expression of Robo4 positively correlated with patients' age (P = 0.0139) and glioma grade (P < 0.0001). 25859844 2015