|
Bicuspid aortic valve
|
0.410 |
Biomarker
|
disease |
BEFREE |
This is consistent with BAV/AscAA-associated findings in patients and in animal models deficient for ROBO4.
|
30455415 |
2019 |
|
Bicuspid aortic valve
|
0.410 |
Biomarker
|
disease |
CTD_human |
This is consistent with BAV/AscAA-associated findings in patients and in animal models deficient for ROBO4.
|
30455415 |
2019 |
|
Bicuspid aortic valve
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
|
Autistic Disorder
|
0.310 |
Biomarker
|
disease |
CTD_human |
Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction.
|
18270976 |
2008 |
|
Autistic Disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction.
|
18270976 |
2008 |
|
Aortic Aneurysm, Thoracic
|
0.300 |
Biomarker
|
disease |
CTD_human |
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
|
30455415 |
2019 |
|
Aortic Aneurysm, Thoracoabdominal
|
0.300 |
Biomarker
|
disease |
CTD_human |
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
|
30455415 |
2019 |
|
Aneurysm of ascending aorta
|
0.110 |
Biomarker
|
phenotype |
BEFREE |
This is consistent with BAV/AscAA-associated findings in patients and in animal models deficient for ROBO4.
|
30455415 |
2019 |
|
Aneurysm of ascending aorta
|
0.110 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Aortic Valve Stenosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Congenital diaphragmatic hernia
|
0.100 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Aneurysm of aortic root
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Aortic Valve Disease 1
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In contrast to so far described exclusive expression of Robo 4 in the tumor vascular network, our analyses showed that in PCa Robo 4 is not only expressed in the tumor stroma but also in cancer epithelial cells.
|
30662335 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Based on the mechanisms described above, we discuss the aberrant expression of Robo4 in angiogenesis-related diseases and propose antiangiogenic therapies targeting the Robo4 signaling pathway for the treatment of ocular neovascularization lesions and tumors.
|
31160487 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Finally, we show that an adjuvant free soluble Robo4-carrier conjugate can retard tumor growth in carrier primed mice.
|
25348086 |
2015 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Here, we intravenously injected an Ad vector containing 3 kb of the human roundabout4 (ROBO4) enhancer/promoter transcriptionally regulating an enhanced green fluorescent protein (EGFP) reporter into immunodeficient mice bearing 786-O renal cell carcinoma subcutaneous (SC) xenografts and kidney orthotopic (KO) tumors.
|
24376772 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Further, immunohistochemical analysis of Robo4 expression in tumor tissue (n = 33) and adjacent non-cancerous tissue (n = 27) was performed.
|
23664449 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The overexpression of Robo1 and Robo4 in tumor vs. normal tissue was verified using real-time PCR.
|
16685377 |
2006 |
|
Diabetic Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
The development of DR increased the levels of HIF-1α, SP1 and ROBO4 both in the DR model and in hyperglycaemic/hypoxic RPE cells.
|
31094072 |
2019 |
|
Diabetic Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
The role of roundabout 4 (Robo 4) in angiogenesis and vasculogenesis is controversial; however, the interdependent relationship between these two factors has not been studied in DR.
|
30980286 |
2019 |
|
Diabetic Retinopathy
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-411 was down-regulated in the rat model of diabetic retinopathy and played a protective role in this disease, which might be achieved by negatively regulating the expression level of ROBO4.
|
31773667 |
2019 |
|
Diabetic Retinopathy
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The expression level of Robo4 increases gradually along with the development of diabetic retinopathy (DR).
|
28341181 |
2017 |
|
Diabetic Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
The RT-qPCR analysis showed that there was a significant increase in Robo4 expression under hyperglycemic conditions, while there was a decrease in expression under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting that Robo4 might play different roles in various stages of DR.
|
27041242 |
2016 |
|
Hyperglycemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
MicroRNA (miRNA)-mediated modulation of VEGF and Robo4 was explored in diabetic rats and ARPE-19 tissue culture cells under hyperglycemia.
|
30980286 |
2019 |