MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 69; N. variants: 0
Disease: Depressive disorder ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET ERK1/2 mRNA expression was down-regulated in the depression model group compared with the normal control group (P<0.01). 21368416 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. 20657013 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Although ERK1/2 has been proposed as a common mediator of antidepressant action in naive rodents, it remains to be determined whether the ERK1/2 pathway plays a role in depressive disorder. 19424057 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate. 17889834 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Mice lacking ERK1 exhibited enhanced fear extinction and reduced depression caused by overactivation of ERK2. 17712345 2008