MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 647; N. variants: 7
Disease: Diabetic Nephropathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.040 AlteredExpression disease BEFREE Angiotensin Ⅱ(Ang Ⅱ) induced activation of ERK1/2 signaling plays important roles in causing apoptosis of podocytes in DN kidneys. 29129692 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.040 Biomarker disease BEFREE These results indicated that knockdown of NLRP3 antagonized HG-induced EMT by inhibiting ROS production, phosphorylation of SMAD3, P38MAPK and ERK1/2, highlighting NLRP3 as a potential therapy target for diabetic nephropathy. 30307163 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.040 Biomarker disease BEFREE These findings demonstrate a novel mechanism that CDK5 increases tubulointerstitial fibrosis by activating the ERK1/2/PPARγ pathway and EMT in DN. 27145370 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.040 AlteredExpression disease BEFREE The Ras GTPase-activating-like protein IQGAP1 is downregulated in human diabetic nephropathy and associated with ERK1/2 pathway activation. 24488174 2014