MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 69; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker disease CTD_human The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. 24763052 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker phenotype CTD_human Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. 22580338 2012
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.400 Biomarker disease CTD_human Collectively, these results suggest that nicotine stimulates gastric cancer cell growth through the activation of beta-adrenoceptors and the downstream PKC-betaI/ERK1/2/COX-2 pathway. 17003101 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.400 Biomarker disease CTD_human Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 11884234 2002
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.400 Biomarker disease CTD_human Vanadium increases GLUT4 in diabetic rat skeletal muscle. 12083368 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.390 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.360 Biomarker disease CTD_human Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. 16211241 2005
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.350 Biomarker phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.350 Biomarker disease PSYGENET ERK1/2 mRNA expression was down-regulated in the depression model group compared with the normal control group (P<0.01). 21368416 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET ERK1/2 mRNA expression was down-regulated in the depression model group compared with the normal control group (P<0.01). 21368416 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.350 Biomarker disease PSYGENET Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. 20657013 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. 20657013 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Although ERK1/2 has been proposed as a common mediator of antidepressant action in naive rodents, it remains to be determined whether the ERK1/2 pathway plays a role in depressive disorder. 19424057 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.350 Biomarker disease PSYGENET The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate. 17889834 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.350 Biomarker disease PSYGENET Mice lacking ERK1 exhibited enhanced fear extinction and reduced depression caused by overactivation of ERK2. 17712345 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate. 17889834 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker disease PSYGENET Mice lacking ERK1 exhibited enhanced fear extinction and reduced depression caused by overactivation of ERK2. 17712345 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.350 Biomarker disease PSYGENET Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure. 15833803 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.350 Biomarker disease CTD_human Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. 16211241 2005
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.350 Biomarker phenotype CTD_human Spinal ERK1/2 activation with capsaicin treatment correlated with the development of prolonged referred hyperalgesia. 12941468 2003
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.350 Therapeutic group CTD_human Cocaine and apoptosis in myocardial cells. 10620750 1999
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 Biomarker disease CTD_human Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity. 30559488 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Both single-gene and gene-set enrichment analyses in genome-wide association data from the largest schizophrenia sample to date of 13,689 cases and 18,226 controls show significant association of HIST1H1E and MAPK3, and enrichment of our PSD proteome. 25048004 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Given the role of ERK1/2, alphaCaMKII and CREB in neuroplastic mechanisms and cell communication, our data suggest that their decreased activation following chronic PCP administration can contribute to cortical defects occurring in schizophrenia, and may therefore represent potential targets for pharmacological intervention. 18406625 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 Biomarker group CTD_human Vanadium increases GLUT4 in diabetic rat skeletal muscle. 12083368 2002