ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We aimed to assess the role of deleterious BARD1 germline variants in BC/OC predisposition in a sample of 4920 BRCA1/2-negative female BC/OC index patients of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC).
|
31036035 |
2019 |
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Significant associations with OC were observed in <i>BRCA1, BRCA2, RAD51C</i> and <i>RAD51D.</i> Other homologous recombination genes, <i>BARD1, NBN,</i> and <i>PALB2,</i> were not significantly associated with OC.
|
31341520 |
2019 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Challenges in Interpreting Germline Mutations in BARD1 and ATM in Breast and Ovarian Cancer Patients.
|
28139868 |
2017 |
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
The BARD1 antibody test is highly specific for lung cancer and not breast or ovarian cancer.
|
28786985 |
2017 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent data indicate that germline mutations of BARD1 may predispose to breast and/or ovarian cancer.
|
26329992 |
2015 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, although we cannot exclude the presence of large mutations in BARD1, our study indicates that such mutations do not contribute substantially to the risk of breast and/or ovarian cancer.
|
25994375 |
2015 |
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10(-4) and 8 x 10(-4), respectively), but no differences for BARD1 (P = .39), NBN1 ( P = .61), or PALB2 (P = .08).
|
26315354 |
2015 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Cancer predisposing BARD1 mutations in breast-ovarian cancer families.
|
21344236 |
2012 |
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
The science behind BARD1 and its role in breast and ovarian cancer is explained in this article.
|
19959210 |
2010 |
ovarian neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
However, cancer-associated mutations of BARD1 are rare; on the contrary, overexpression of truncated BARD1 was found in breast and ovarian cancer and correlated with poor prognosis.
|
17556008 |
2007 |
ovarian neoplasm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Expression of NH(2) terminally truncated BARD1 was correlated with advanced stage of cancer, and expression of spliced isoforms was typical for clear cell carcinoma, the ovarian cancer with worst prognosis, suggesting a role of BARD1 isoforms in cancer progression.
|
18089818 |
2007 |
ovarian neoplasm
|
0.200 |
PosttranslationalModification
|
disease |
LHGDN |
Maximal BARD1 expression was associated with the most malignant ovarian cancer, clear cell carcinoma.
|
16152612 |
2006 |
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Several studies have indicated that the BARD1 gene is a potential target for germline changes predisposing to breast and ovarian cancer.
|
16825437 |
2006 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
To investigate whether alterations in BARD1 are involved in human breast and ovarian cancer, we used single strand conformation polymorphism analysis and sequencing on 35 breast tumours and cancer cell lines and on 21 ovarian tumours.
|
16061562 |
2005 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether alterations in BARD1 are involved in human breast and ovarian cancer, we used single strand conformation polymorphism analysis and sequencing on 35 breast tumours and cancer cell lines and on 21 ovarian tumours.
|
16061562 |
2005 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The involvement of BARD1 mutations in the susceptibility to hereditary breast and breast/ovarian cancer is discussed.
|
11807980 |
2002 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The involvement of BARD1 mutations in the susceptibility to hereditary breast and breast/ovarian cancer is discussed.
|
11807980 |
2002 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, a germline alteration of BARD1 was identified in a clear cell ovarian tumor (Gln564His); again, loss of the wild-type BARD1 allele was observed in the malignant cells of this patient.
|
9425226 |
1998 |
ovarian neoplasm
|
0.200 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
ovarian neoplasm
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|