Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of B cell leukemia/lymphoma (Bcl‑2), Bcl‑2 associated X (Bax), cyclin dependent kinase 4 (CDK4), cyclin D1 and p21 were evaluated using reverse transcription‑polymerase chain reaction and western blot analysis, respectively.
|
29115462 |
2018 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunophenotypic analysis showed that the lymphoma cells were positive for cyclin D1 (n=16/16), Myc (9/11), and P53 (n=9/9).
|
27776009 |
2017 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this isotype was the most effective in eradicating BCL1 lymphoma but had limited efficacy in s.c. tumors.
|
29109120 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1-positive large B-cell lymphoma is rare, but as large B-cell lymphoma is a common type of lymphoma, cyclin D1-positive large B-cell lymphoma should be considered a major possibility during differential diagnosis, including in the tonsils.
|
28296741 |
2017 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All 1292 reactive lymph nodes from unselected consecutive surgical specimens of 131 patients without a history of lymphoma obtained over a 3-month period were stained for cyclin D1.
|
22790016 |
2012 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein synthesis inhibitor silvestrol has potent activity in B-cell leukemias via the mitochondrial pathway of apoptosis, and also reduces cyclin D1 expression in breast cancer and lymphoma cell lines.
|
22791882 |
2012 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, cyclin-D1 inhibition sensitized the lymphoma cells to apoptosis through BAX release.
|
21746927 |
2011 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 overexpression is a hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 have not been shown to be closely associated with any particular subtype of lymphoma.
|
21790895 |
2011 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.
|
21281227 |
2011 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that cyclin-D2 and D3 proteins are expressed in many more lymphoma subtypes than cyclin-D1.
|
20062012 |
2010 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant Cyclin D1 expression seems to promote proliferation in other types of lymphoma, while a growth promoting CCND1/TACSD1(TROP2) fusion product has also been described in tumors.
|
19554511 |
2009 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We implemented a system based on this specificity to investigate the mechanism of BCL1 lymphoma protection induced by DNA immunisation.
|
15692846 |
2005 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human blood cancers, loss of Rb expression has been widely reported in both acute myeloblastic and acute lymphoblastic leukemias, cyclin D1 amplification is common in mantle cell lymphoma, and silencing of the p16/INK4a tumor suppressor gene occurs frequently in AML and various types of lymphoma.
|
15611658 |
2005 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1.
|
15239399 |
2004 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the 23 validated genes were cyclin D1 (CCND1) and B-cell CLL/lymphoma 2, which have well-known roles in lymphoma pathogenesis.
|
14961037 |
2004 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In parallel, we investigated the relationship between p27(Kip1), the lymphoma proliferation index, Epstein-Barr virus status, expression of cellular cyclin D3 and cyclin D1, and B-cell differentiation stage.
|
12107101 |
2002 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified 25 cases (48 samples) of bcl-1+ and CD5- lymphoma.
|
12162681 |
2002 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Statistical analysis of the expression data revealed the combination of CCND1 and CDK4 as the best classifier concerning separation of both lymphoma types.
|
12036888 |
2002 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To compare the expression status of G1 cyclins, these EBV-associated lymphoma lines (6 EBV[-] human SCID mouse lymphoma lines, 13 human B cell lymphomas and 8 samples of human tonsil tissue) were examined by reverse transcription-polymerase chain reaction-Southern blotting, Western blotting and immunohistochemistry. mRNA expression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), cyclin-dependent kinase 2 (CDK2) and 4 (CDK4) was found in all 3 types of lymphomas.
|
11291051 |
2001 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latter parameters and IPI were the only ones with independent prognostic value (RR = 10, 5.0, 6.7, and 3.7, respectively; P < 0.001) when assessed together with lymphoma sub-type, primary versus relapse cases, treatment, B symptoms, S phase fraction, and presence of BCL1 and BCL2 translocations.
|
11747333 |
2001 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we analysed 34 de novo diffuse large B cell lymphoma (DLCL) from a population-based lymphoma registry for alterations of the RB1 pathway at the genetic (RB1 and CDK4) and protein (pRb, cyclin D1, cyclin D3, CDK4, and E2F-1) level.
|
10803523 |
2000 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined 151 cases of lymphoma with MCL morphology from a viewpoint of cyclin D1 overexpression, which is now easily detectable by immunohistochemistry.
|
10733493 |
2000 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lymphoma cell lines harboring the t(11;14) showed cyclin D1 protein but no or very low levels of cyclin D3; three other B-cell lines, a T-cell line, and peripheral blood lymphocytes strongly expressed cyclin D3 and reacted negatively for cyclin D1.
|
9376597 |
1997 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the known lymphoma-associated chromosomal changes or rearrangements of the BCL1, BCL2, BCL3, BCL6, and CMYC genes were detected.
|
8547655 |
1996 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, the recognition of chromosomal translocations which have activated the BCL1 and BCL2 proto-oncogenes have strong associations with specific types of non-Hodgkin's malignant lymphomas such as mantle cell lymphoma and follicular center cell lymphoma, respectively.
|
8852399 |
1995 |