Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic factor (BDNF), proteins previously associated with cognition and epilepsy, on cognitive function in people with newly diagnosed epilepsy.
|
26708060 |
2016 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the protection against neuronal loss in specific limbic regions and overexpressed BDNF in the mossy fibers resulting from the repeated treatment with Ago and LCM, respectively, during SE is not a prerequisite for alleviation of epileptogenesis and development of epilepsy.
|
30738136 |
2019 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Epilepsy is frequent and has been reported to correlate with mutation type, general disease severity, and BDNF polymorphism.
|
20491871 |
2010 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review article, we discuss recent finding illuminating how mBDNF-TrkB and proBDNF-p75<sup>NTR</sup> signaling pathways regulate GABA related neurotransmission under physiological conditions and during epilepsy.
|
30210299 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF has emerged as one of the most important signaling molecules for the developing nervous system as well as the impaired nervous system, and multiple diseases, such as Alzheimer's, Parkinson's, Huntington's, epilepsy, Rett's syndrome, and psychiatric depression, are linked by their association with potential dysregulation of BDNF-driven signal transduction programs.
|
18208542 |
2008 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine whether a common polymorphism of the brain-derived neurotrophic factor (BDNF), which constitutes an important and ubiquitously expressed neurotrophine in the brain, affects the stimulation threshold of ECTs required to induce an epileptic seizure over time.
|
27787610 |
2017 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role?
|
21890420 |
2011 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development.
|
16388108 |
2006 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that BDNF and its receptor may play a local role within the hippocampus in kindling-associated neural plasticity and in neuronal protection following epileptic, ischemic, and hypoglycemic insults.
|
8439408 |
1993 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present results demonstrated that inhibition of Kir4.1 channels facilitates BDNF expression in astrocytes primarily by activating the Ras/Raf/MEK/ERK pathway, which may be linked to the development of epilepsy and other neuropsychiatric disorders.
|
29358904 |
2017 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples.
|
26621122 |
2016 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with miR-103a inhibitors alone, epilepsy rats treated with BDNF-siRNA combined with miR-103a inhibitors significantly increased expression of GFAP in hippocampal tissues of epilepsy rats, increased number of apoptotic neurons and significantly decreased the number of surviving neurons.
|
31049031 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There also was a significant negative correlation between the duration of epilepsy and the expression of mRNA for brain-derived neurotrophic factor.
|
10713570 |
2000 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.
|
31400269 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed.
|
31377199 |
2020 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR).
|
24737869 |
2014 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway.
|
30805931 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed plasma [corrected] BDNF immunoreactivity in 15 patients with ES, 12 patients with PNES, and 17 healthy volunteers.
|
20921514 |
2010 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy.
|
30524358 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy.
|
28527108 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
|
30741614 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the full agonist effects of brain-derived neurotrophic factor and tropomyosin receptor kinase B activation in epilepsy models have been controversial, the present results indicate that such trophic activation by a partial agonist may potentially serve as an effective therapeutic option for prophylactic treatment of posttraumatic epileptogenesis, and treatment of other neurological and psychiatric disorders whose pathogenesis involves impaired parvalbumin interneuronal function.
|
29408225 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pathologic levels of BDNF-dependent synaptic plasticity may contribute to conditions such as epilepsy and chronic pain sensitization, whereas application of the trophic properties of BDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
|
15518235 |
2004 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling.
|
28492982 |
2018 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, whether BDNF Val66Met polymorphism is associated with epilepsy remains controversial.
|
26000807 |
2016 |