Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed.
|
31377199 |
2020 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the protection against neuronal loss in specific limbic regions and overexpressed BDNF in the mossy fibers resulting from the repeated treatment with Ago and LCM, respectively, during SE is not a prerequisite for alleviation of epileptogenesis and development of epilepsy.
|
30738136 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with miR-103a inhibitors alone, epilepsy rats treated with BDNF-siRNA combined with miR-103a inhibitors significantly increased expression of GFAP in hippocampal tissues of epilepsy rats, increased number of apoptotic neurons and significantly decreased the number of surviving neurons.
|
31049031 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.
|
31400269 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway.
|
30805931 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
|
30741614 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously found that neurons respond to prolonged BDNF exposure (both in vivo (in models of epilepsy and TBI) and in vitro (in BDNF treated primary neuronal cultures)) by activating the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway.
|
31455240 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population.
|
30909076 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review article, we discuss recent finding illuminating how mBDNF-TrkB and proBDNF-p75<sup>NTR</sup> signaling pathways regulate GABA related neurotransmission under physiological conditions and during epilepsy.
|
30210299 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy.
|
30524358 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy.
|
28527108 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the full agonist effects of brain-derived neurotrophic factor and tropomyosin receptor kinase B activation in epilepsy models have been controversial, the present results indicate that such trophic activation by a partial agonist may potentially serve as an effective therapeutic option for prophylactic treatment of posttraumatic epileptogenesis, and treatment of other neurological and psychiatric disorders whose pathogenesis involves impaired parvalbumin interneuronal function.
|
29408225 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling.
|
28492982 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We targeted those publications addressing both in vitro and in vivo evidences of relationship between BDNF and epilepsy.
|
30262417 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rats with epilepsy presented decreased BDNF levels compared with control rats.
|
29098710 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, ECB device-mediated long-term supplementation of BDNF in the epileptic tissue may represent a valid therapeutic strategy against epilepsy and some of its co-morbidities.
|
29766029 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine whether a common polymorphism of the brain-derived neurotrophic factor (BDNF), which constitutes an important and ubiquitously expressed neurotrophine in the brain, affects the stimulation threshold of ECTs required to induce an epileptic seizure over time.
|
27787610 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present results demonstrated that inhibition of Kir4.1 channels facilitates BDNF expression in astrocytes primarily by activating the Ras/Raf/MEK/ERK pathway, which may be linked to the development of epilepsy and other neuropsychiatric disorders.
|
29358904 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels.
|
28078614 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of brain-derived neurotrophic factor (BDNF) in the CA3 area of the hippocampus in the comorbidity group was significantly higher than that in the epilepsy group according to the immunohistochemical test (P<0.05).
|
28559979 |
2017 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic factor (BDNF), proteins previously associated with cognition and epilepsy, on cognitive function in people with newly diagnosed epilepsy.
|
26708060 |
2016 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples.
|
26621122 |
2016 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, whether BDNF Val66Met polymorphism is associated with epilepsy remains controversial.
|
26000807 |
2016 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.
|
25876511 |
2016 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR).
|
24737869 |
2014 |