S100B, S100 calcium binding protein B, 6285

N. diseases: 44; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. 20398908 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Fine-mapping analyses of 21q22 have previously identified transient receptor potential gene melastatin 2 (TRPM2), which is 2 Mb upstream of S100B, as a possible BPAD susceptibility gene at 21q22. 17525977 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease CTD_human Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. 15581912 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. 20962330 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Although it may be open for discussion whether the neuroprotective effects of ONO-2506 are exclusively due to its inhibition of S100B synthesis, the latter action of ONO-2506 warrants studies of the effects of this drug in the pathobiology of depression. 16797859 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET S100 beta, a calcium binding brain protein expressed by astrocytes, has been shown to be involved in higher neural processes, including hippocampal-dependent behavioral traits and hippocampal neuronal long-term potentiation (LTP) and depression (LTD), neurophysiological phenomena that may be involved in exploring, learning and remembering novel stimuli. 8804639 1996
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET S100 beta, a calcium binding astrocytic brain protein, influences hippocampal long-term potentiation (LTP) and depression (LTD), synaptic processes suggested to play role in spatial (contextual) learning and memory. 8840925 1996
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.530 Biomarker disease CTD_human We now extend this work by showing that S100beta is induced in hearts of human subjects after myocardial infarction. 9788975 1998
CUI: C0018944
Disease: Hematoma
Hematoma 		0.500 Biomarker phenotype CTD_human The single measurement of serum S100B at 6 h after ICH induction was significantly correlated with brain edema formation and the maximal extent of the hematoma volumes. 19027832 2009
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.500 Biomarker phenotype CTD_human The single measurement of serum S100B at 6 h after ICH induction was significantly correlated with brain edema formation and the maximal extent of the hematoma volumes. 19027832 2009
CUI: C0005587
Disease: Depression, Bipolar
Depression, Bipolar 		0.500 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
CUI: C0024713
Disease: Manic Disorder
Manic Disorder 		0.500 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
CUI: C0005587
Disease: Depression, Bipolar
Depression, Bipolar 		0.500 Biomarker disease CTD_human Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2004
CUI: C0024713
Disease: Manic Disorder
Manic Disorder 		0.500 Biomarker disease CTD_human Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. 22146151 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET These results implicate a role for S100B gene polymorphisms in the cognitive functions of schizophrenia patients and encourage further investigation into spatial disability as an endophenotype of schizophrenia. 21070816 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. 20962330 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. 20398908 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Although it may be open for discussion whether the neuroprotective effects of ONO-2506 are exclusively due to its inhibition of S100B synthesis, the latter action of ONO-2506 warrants studies of the effects of this drug in the pathobiology of depression. 16797859 2006
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.400 Biomarker disease CTD_human Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome. 12888777 2003