SKP2, S-phase kinase associated protein 2, 6502

N. diseases: 204; N. variants: 3
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease BEFREE Collectively, our findings identify Skp2-mediated K63-linked polyubiquitination as a critical regulatory mechanism responsible for MTH1 upregulation in melanoma, with potential implications to target the MAPK/Skp2/MTH1 pathway to improve its treatment.<i></i>. 28947420 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.070 Biomarker disease BEFREE In summary, our results integrated TGF-β1 signals to SKP2 via Akt1 and c-Myc during EMT, and provided, to our knowledge, a previously unreported mechanistic molecular event for TGF-β1-induced metastasis in human melanoma. 23792459 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease LHGDN In mutant p53 melanoma lines, Skp2 depletion did not induce cell cycle arrest despite up-regulation of p27(Kip1). 18716061 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease BEFREE Reduced Cks1 or Skp2 expression and enhanced p27(Kip1) levels inhibit melanoma cell growth. 16924241 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease LHGDN Reduced Cks1 or Skp2 expression and enhanced p27(Kip1) levels inhibit melanoma cell growth. 16924241 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.070 GeneticVariation disease BEFREE Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. 16052531 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease LHGDN Our data suggests that Skp2 could contribute to melanoma progression. 15736055 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.070 AlteredExpression disease LHGDN Skp2 cytoplasmic labeling index of >20% predicted worse 10-year overall survival (38% vs. 86%, p = 0.04) in primary melanoma. 15491322 2004