SLC6A2, solute carrier family 6 member 2, 6530

N. diseases: 41; N. variants: 2
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Compared with VM rats, the PM rats showed significant relief of depression-like behaviors, decrease in the malondialdehyde level, increase in superoxide dismutase and catalase activities, and increase in 5-HTT and NET expression. 23636256 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population. 23969988 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. 24655776 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population. 23969988 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. 24655776 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Compared with VM rats, the PM rats showed significant relief of depression-like behaviors, decrease in the malondialdehyde level, increase in superoxide dismutase and catalase activities, and increase in 5-HTT and NET expression. 23636256 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. 24655776 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET SLC6A2 variants may predict remission from major depression after venlafaxine treatment in Han Chinese population. 25512257 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression. 25650523 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET This study attempted to examine the relationship between polymorphisms of NET gene and MD. 26061302 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Methylation of the SLC6a2 gene promoter in major depression and panic disorder. 24312678 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET Patients with MDD or panic disorder were not found to differ significantly from healthy controls in the pattern of methylation of the SLC6a2 gene promotor. 24312678 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET There were no relationships between lethality scores and SLC6A2 polymorphisms in suicidal MDD. 24655776 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET This study attempted to examine the relationship between polymorphisms of NET gene and MD. 26061302 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD). 25650523 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET The aim of this study was to examine whether polymorphisms in the norepinephrine transporter gene (SLC6A2) associate with remission after venlafaxine treatment for MDD. 25512257 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET No association was found between the studied polymorphism of the NET gene and either bipolar disorder or schizophrenia. 12097806 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. 20543991 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET Therefore we tested whether norepinephrine transporter (NET) gene variants confer susceptibility to either alcohol dependence or severe alcohol withdrawal symptoms. 12374639 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET We therefore demonstrate an association of SLC6A2 and ADRA2A with adult alcoholism. 21070505 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms. 19650813 2009