SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 75; N. variants: 6
Disease: Depressive disorder ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease PSYGENET Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. 25583186 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease PSYGENET The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. 25510949 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease PSYGENET Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression. 23588187 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease CTD_human The smaller effects of the 5-HTT polymorphism on depression may be explained by an interaction between the genes (F = 5.0, d.f. 18458677 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347 2003