|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
The majority utilized PGT-A on their first IVF cycle, most commonly to 'maximize the efficiency of IVF' or reduce per-transfer miscarriage risk.
|
31220868 |
2019 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
The transfers of "abnormal" embryos by PGT-A offered robust pregnancy and live birth chances with low miscarriage rates.
|
31236830 |
2019 |
|
Miscarriage
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The main indications of PGT-A are advanced maternal age, repeated implantation failure, repeated miscarriages and severe male infertility.
|
31082515 |
2019 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, the number of patients with two or more previous miscarriages was significantly greater in the PGT-A group as compared to controls, however a sub-analysis showed that this failed to impact outcomes.
|
30500907 |
2019 |
|
Miscarriage
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent advances in PGT-A increase the detection of embryos with mosaicism, which is associated with an increased risk of miscarriage, fetal mosaic aneuploidy, and uniparental disomy.
|
30624282 |
2019 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
PGT-A could not improve the live births per patient nor reduce the rate of miscarriage, in both groups.
|
31811307 |
2019 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preimplantation genetic testing for aneuploidy (PGT-A) has been demonstrated to improve implantation and pregnancy rates and decrease miscarriage rates over standard morphology-based embryo selection.
|
29697414 |
2018 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preimplantation genetic testing for aneuploidy (PGT-A) aims to avoid miscarriage and live born trisomic offspring and to improve IVF success.
|
29945889 |
2018 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
PGT-A allows for better embryo selection, which improves implantation rates with single embryo transfer and reduces miscarriage rates.
|
30146380 |
2018 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
For patients with > 1 embryo, IVF with PGT-A reduces healthcare costs, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage when compared to IVF alone.
|
30316435 |
2018 |
|
Miscarriage
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among those who decided to undergo PGT-A, 56% stated their primary reason was to have a healthy baby, while 18% chose PGT-A to reduce the incidence of birth defects, and 16% aimed to decrease the risk of miscarriage.
|
30334131 |
2018 |