SUMO2, small ubiquitin like modifier 2, 6613

N. diseases: 42; N. variants: 3
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.010 AlteredExpression phenotype BEFREE These findings indicate that while endogenous SUMO2 is important in maintenance of normal endothelium-dependent vascular function, its upregulation impairs vascular homeostasis and contributes to hypercholesterolemia-induced endothelial dysfunction.<b>NEW & NOTEWORTHY</b> Sumoylation is known to impair vascular function; however, the role of specific SUMOs in the regulation of vascular function is not known. 31584834 2019