TIMP2, TIMP metallopeptidase inhibitor 2, 7077

N. diseases: 404; N. variants: 20
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 GeneticVariation disease BEFREE The aim of this study was to investigate the disease-specific urinary levels variations of neurotrophins (NGF, BDNF), mediators of inflammation (TGFβ-1, PGE-2) and markers of extracellular matrix alterations (TIMP-2) in patients with multiple sclerosis (MS) spinal cord injury (SCI), or spina bifida (SB), and neurogenic detrusor overactivity (NDO). 31741027 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 GeneticVariation disease BEFREE The roles of MMP2-1306 C/T and TIMP2-418 G/C genetic variants in MS have not been studied before. 27174941 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 AlteredExpression disease LHGDN We studied the relationships between serum MMP-9, MMP-2, TIMP-1 and TIMP-2 and different magnetic resonance imaging (MRI) measures of disease activity in MS patients during treatment with rIFNbeta-1a. 16042227 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 Biomarker disease BEFREE Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-gamma and -beta: implications to multiple sclerosis. 12458052 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 Biomarker disease BEFREE However, unbound TIMP-2 in plasma was significantly higher in MS patients compared to healthy controls. 10496173 1999
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.060 Biomarker disease BEFREE We investigated mRNA expression of MMP-3, MMP-9 and two tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in parallel in blood mononuclear cells (MNC) from patients with MS and controls, using in situ hybridization. 10330301 1999