TIMP2, TIMP metallopeptidase inhibitor 2, 7077

N. diseases: 404; N. variants: 20
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 Biomarker disease BEFREE During liver fibrosis resolution, in the absence of MMP9, the ratio of (MMP9 + MMP13)/TIMP1 and the ratio of (MMP2+ MMP14)/TIMP2 were decreased, and the collagen levels were increased. 31638220 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 Biomarker disease BEFREE The increased MMP-2/TIMP-2 and suppressed MMP-9/TIMP-1 ratios in IHC and in real-time polymerase chain reaction (RT-PCR) seemed to correlate with the degree of liver fibrosis. 30019784 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 AlteredExpression disease BEFREE These data indicated that extracts from Ceratonia siliqua pods may play an important role in combating schistosomal hepatopathology and may inhibit granuloma formation and liver fibrosis through down-regulation of TIMP-2 expression. 27821159 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 GeneticVariation disease BEFREE These results suggest that faster progression of liver fibrosis could be associated with TIMP-2 -418 G homozygotes. 23563628 2013
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 Biomarker disease BEFREE Methodologic research on TIMP-1, TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance. 11925608 2002
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.060 Biomarker disease BEFREE Dysregulation of TIMP-2 synthesis might be involved in the development of liver fibrosis. 8001673 1995