TPH1, tryptophan hydroxylase 1, 7166

N. diseases: 127; N. variants: 11
Disease: Nicotine Dependence ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.020 GeneticVariation disease BEFREE Results yield support for previous findings of an association between the AA genotype of TPH1 779A/C and nicotine status and a tendency for a heterosis effect with respect to the degree of nicotine dependence. 17986837 2007
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.020 Biomarker disease BEFREE The positive heterosis effects with respect to nicotine addiction and personality support the idea that the TPH1 gene exerts pleiotropic effects. 15635702 2005