TYK2, tyrosine kinase 2, 7297

N. diseases: 172; N. variants: 22
Disease: Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 GeneticVariation group BEFREE Lymphomas in this model lacking Tyk2 have reduced STAT1 and STAT3 phosphorylation and reduced expression of Mcl1, a pro-survival member of the BCL2 family. 30131584 2019
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 Biomarker group BEFREE The CTLA4-Tyk2-STAT3 signal pathway was also active in tumor-associated nonmalignant B cells in mouse models of melanoma and lymphoma. 28716895 2017
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 Biomarker group BEFREE Finally, short hairpin RNA-mediated silencing of TYK2 abrogated lymphoma cell growth. 25349176 2014
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 Biomarker group BEFREE RAG2/TYK2 double-knockout mice succumbed to A-MuLV-induced leukemia/lymphoma faster than RAG2(-/-)TYK2(+/-) mice. 15578097 2004