TYK2, tyrosine kinase 2, 7297

N. diseases: 172; N. variants: 22
Disease: Myeloproliferative disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.030 Biomarker group BEFREE Loss of Tyrosine Kinase 2 Does Not Affect the Severity of <i>Jak2</i>V617F-induced Murine Myeloproliferative Neoplasm. 28668884 2017
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.030 Biomarker group BEFREE Although the Janus family of kinases (JAK1, JAK2, JAK3, and TYK2) has been extensively characterized and investigated, the role of Janus kinase activation in the pathogenesis and therapy of human malignancies was not fully appreciated until recently when multiple studies identified a recurrent somatic mutation in the JAK2 tyrosine kinase (JAK2V617F) in the majority of patients with BCR-ABL-negative myeloproliferative neoplasms (MPN), polycythemia vera, essential thrombocytosis, and primary myelofibrosis. 21823028 2012
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.030 Biomarker group BEFREE Tyk2 is dispensable for induction of myeloproliferative disease by mutant FLT3. 16867903 2006