|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ZNF804A and CACNA1C loci appear to influence risk for both disorders, a finding that supports the hypothesis that schizophrenia and BD are not aetiologically distinct.
|
19521722 |
2009 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder and ZNF804A in schizophrenia and a relatively specific association between common variation in GABA(A) receptor genes and cases with features of both bipolar disorder and schizophrenia.
|
19329560 |
2009 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.
|
19621016 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, a gene coding for a calcium channel subunit (CACNA1C: calcium channel, voltage-dependent, L type, alpha 1C subunit) is discussed in the light of schizophrenia whereas genetic findings related to alterations in the intracellular Ca-homeostasis associated specifically with dopaminergic and serotonergic neurotransmission in schizophrenia are not herein closer reviewed.
|
20600464 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A case-control analysis was used to determine the association of CACNA1C genotype with schizophrenia.
|
20819988 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The finding for CACNG5, taken together with the earlier implication of CACNA1C and CACNA1B, strongly suggests a key role for voltage-dependent calcium channel genes in the susceptibility to bipolar disorder and/or schizophrenia.
|
21057379 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies five new schizophrenia loci.
|
21926974 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous data have also directly implicated one of the best supported schizophrenia-associated loci, zinc finger binding protein 804A (ZNF804A), as showing trans-disorder effects, and the same is true for one of the best supported bipolar loci, calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) which has also been associated with schizophrenia.
|
21037240 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4.
|
21926972 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
OBJECTIVES.The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ).
|
21767209 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder.
|
22012475 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals.
|
22957138 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
|
22688191 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
|
22688191 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that CACNA1C is involved in the genetic architecture of endophenotypes for affective disorders and schizophrenia, and that it shows a distinct sex-specific effect.
|
22665259 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.
|
23637625 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
CACNA1C is unlikely to play a major role in the pathophysiology of schizophrenia in Han Chinese.
|
23900723 |
2013 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
After combining the new schizophrenia data with those of the PGC, variants at three loci (ITIH3/4, CACNA1C and SDCCAG8) that had not previously been GWS in schizophrenia attained that level of support.
|
22614287 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results provide further support for associations of rs1006737 and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations.
|
24355530 |
2014 |