Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
CACNA1C is unlikely to play a major role in the pathophysiology of schizophrenia in Han Chinese.
|
23900723 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study.
|
31061683 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A case-control analysis was used to determine the association of CACNA1C genotype with schizophrenia.
|
20819988 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
After combining the new schizophrenia data with those of the PGC, variants at three loci (ITIH3/4, CACNA1C and SDCCAG8) that had not previously been GWS in schizophrenia attained that level of support.
|
22614287 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
|
31268507 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations of schizophrenia risk genes ZNF804A and CACNA1C with schizotypy and modulation of attention in healthy subjects.
|
31076262 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Biological insights from 108 schizophrenia-associated genetic loci.
|
25056061 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory.
|
28607492 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common and rare variants of the CACNA1C voltage-gated calcium channel gene have been associated with autism and other neurodevelopmental disorders including schizophrenia, bipolar disorder and ADHD.
|
31805042 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
|
29483656 |
2018 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals.
|
22957138 |
2012 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4.
|
21926972 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study.
|
29503163 |
2018 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Further imaging genetic investigations on the mediating effect of CACNA1C in schizophrenia can uncover brain circuitries involved in schizophrenia and suggest potential novel targets for intervention.
|
25470093 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further imaging genetic investigations on the mediating effect of CACNA1C in schizophrenia can uncover brain circuitries involved in schizophrenia and suggest potential novel targets for intervention.
|
25470093 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further research is needed to examine the functions of CACNA1C and ANK3, and their interacting partners in the molecular, developmental, and pathophysiological processes in SZ.
|
26227746 |
2015 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, a gene coding for a calcium channel subunit (CACNA1C: calcium channel, voltage-dependent, L type, alpha 1C subunit) is discussed in the light of schizophrenia whereas genetic findings related to alterations in the intracellular Ca-homeostasis associated specifically with dopaminergic and serotonergic neurotransmission in schizophrenia are not herein closer reviewed.
|
20600464 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common.
|
28792954 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Ca<sub>v</sub> 1.2, is associated with clinical diagnoses of bipolar disorder, depression and schizophrenia.
|
28186690 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
|
28991256 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women.
|
30124797 |
2019 |