AXIN1, axin 1, 8312

N. diseases: 118; N. variants: 19
Disease: Liver neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.020 GeneticVariation group BEFREE Using both human HCC collections and engineered mouse models of liver cancers with AXIN1 mutation or deletion, we defined a common signature of liver tumors mutated for AXIN1 and demonstrate that these tumors occur independently of the activation of the Wnt/β-catenin pathway. 29525529 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.020 GeneticVariation group BEFREE Evidence for a crucial role of the reactivation of the Wnt/beta-catenin pathway, through mutations in the beta-catenin and axin genes in 30-40% of liver tumors, represents a major breakthrough. 10936068 2000