AXIN1, axin 1, 8312

N. diseases: 118; N. variants: 19
Disease: Hepatocarcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.030 Biomarker disease BEFREE In striking contrast, blocking the Notch cascade through expression of either the dominant negative form of the recombinant signal-binding protein for immunoglobulin kappa J region (RBP-J) or the ablation of Notch2 did not significantly affect c-Met/sgAxin1-driven hepatocarcinogenesis. 30737831 2019
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.030 Biomarker disease BEFREE Moreover, association of mutations in specific genes (RPS6KA3-AXIN1 and NFE2L2-CTNNB1) suggested that Wnt/β-catenin signaling might cooperate in liver carcinogenesis with both oxidative stress metabolism and Ras/mitogen-activated protein kinase (MAPK) pathways. 22561517 2012
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.030 AlteredExpression disease BEFREE Therefore, activation of Wnt signaling through AXIN1 rather than beta-catenin mutation might play an important role in liver carcinogenesis. 18171349 2008