Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Leukoencephalopathy, Progressive Multifocal
0.030 Biomarker disease BEFREE UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. 18413804 2008
Leukoencephalopathy, Progressive Multifocal
0.030 AlteredExpression disease BEFREE In U937 myeloid precursor cells, PRAM-1 expression is inhibited by expression of PML-RARalpha in the absence of ligand and de novo superinduced by retinoic acid. 11301322 2001
Leukoencephalopathy, Progressive Multifocal
0.030 Biomarker disease BEFREE The therapeutic effect of ATRA in APL has been associated with the direct modulation of PML-RAR alpha, the restoration of the differentiation pathways regulated by wild-type RAR/retinoid X receptor heterodimer and PML. 9535176 1998