|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling and oncogenesis.
|
15592498 |
2005 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis.
|
27986126 |
2016 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
It has been suggested that caveolin-1 (Cav-1) may contribute to certain steps of carcinogenesis.
|
21039037 |
2010 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Functionally, we demonstrate that fibroblasts co-cultured with MCF7 breast cancer cells acquire a cancer associated fibroblast phenotype, characterized by Cav-1 downregulation, increased expression of myofibroblast markers and extracellular matrix proteins, and constitutive activation of TGFβ/Smad2 signaling. siRNA-mediated Cav-1 downregulation mimics several key changes that occur in co-cultured fibroblasts, clearly indicating that a loss of Cav-1 is a critical initiating factor, driving stromal fibroblast activation during tumorigenesis.
|
20562526 |
2010 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Although none of these four genes showed significant expression differences between PCa ERG+ and PCa ETS-, CAV1, IGFBP3 and TGFBR2 were less expressed in PCa in an independent series of 56 PCa and 15 NPT, as also observed for ECRG4 and LDOC1, suggesting a role in prostate carcinogenesis in general.
|
23185447 |
2012 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Moreover, changes in caveolin-1 play an important role in tumorigenesis and inflammatory processes.
|
30742851 |
2019 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV1) has been implicated in the regulation of several signaling pathways and in oncogenesis.
|
19609943 |
2010 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Lack of caveolin-1 expression has been implicated in the pathogenesis of oncogenic cell transformation and tumorigenesis in many cancers.
|
16865235 |
2006 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of Cav-1 in nasopharyngeal carcinoma (NPC) may enhance tumor cell migration and correlate with poor prognosis of the patients, while the genetic alterations of Cav-1 during nasopharyngeal carcinogenesis are still largely unknown.
|
21965789 |
2011 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV1) is the main protein in the caveolin family and plays an important role in tumorigenesis signaling.
|
25117072 |
2014 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (Cav-1) and Actin-Related Protein 2/3 Complex, Subunit 1B (ARPC1B) have been implicated in various human cancers, yet its role in tumorigenesis remains controversial.
|
26138391 |
2016 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The role of Cav-1 in tumorigenesis, including dysregulation of cell cycle, apoptosis and autophagy, adhesion, invasion, and metastasis, such as the formation of invadopodia and matrix metalloproteinase degradation are presented in detail.
|
31759347 |
2019 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized.
|
29141593 |
2017 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Based on high sequence homology between the murine and human caveolin-1 promoters, we proposed that ETS proteins might regulate caveolin-1 expression in human lung tumorigenesis.
|
19483189 |
2009 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
CAV-1 is the main structural protein component of caveolae, playing important roles in tumorigenesis and tumor development.
|
24842472 |
2014 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV-1) is a main structural protein of caveolae and plays a regulatory role in signaling pathways and tumorigenesis.
|
23393366 |
2013 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
This study aimed to investigate the expression profile of Cav-1 in carcinogenesis and development of TSCC by QDs immunofluorescence histochemistry (QDs-IHC) and discuss the relationship between the Cav-1 expression and the clinicopathological outcomes.
|
20558341 |
2010 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our results would be consistent with the interpretation that caveolin-1 may have tumor suppressing functions during early stages of colon carcinogenesis.
|
18444242 |
2008 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, Cav-1 may have an important role in the carcinogenesis and progression of HBV-associated HCC and angiogenesis may be affected by Cav-1 during this process.
|
29067114 |
2017 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 has been implicated in cellular transformation and tumorigenesis.
|
15331180 |
2004 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the rate of CAV-1 protein overexpression was significantly higher in HCC with cirrhosis than HCC without cirrhosis, suggesting that the CAV-1 protein overexpression likely initiated carcinogenesis in liver with cirrhosis and subsequently contributed to the progression of HCC.
|
31239768 |
2019 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The cultures showed a 2-fold decrease in the expression of the gene coding for the tumor suppressor caveolin-1, and increased expression of the oncogene C-myc, a promoter of cervical carcinogenesis.
|
16005053 |
2005 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 is an essential structural constituent of caveolae membrane domains that has been implicated in mitogenic signaling and oncogenesis.
|
18778685 |
2008 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The alteration of caveolin-1 (Cav-1) during carcinogenesis is of great interest and its over-expression in the tumor cell cytoplasm can predict a poor prognosis of renal cell carcinoma (RCC).
|
25246063 |
2014 |
|
Carcinogenesis
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Our aim was to investigate whether and at which neoplastic stage promoter hypermethylation of CAV1 is involved in human esophageal carcinogenesis.
|
24885118 |
2014 |