Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Moreover, changes in caveolin-1 play an important role in tumorigenesis and inflammatory processes.
|
30742851 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The role of Cav-1 in tumorigenesis, including dysregulation of cell cycle, apoptosis and autophagy, adhesion, invasion, and metastasis, such as the formation of invadopodia and matrix metalloproteinase degradation are presented in detail.
|
31759347 |
2019 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the rate of CAV-1 protein overexpression was significantly higher in HCC with cirrhosis than HCC without cirrhosis, suggesting that the CAV-1 protein overexpression likely initiated carcinogenesis in liver with cirrhosis and subsequently contributed to the progression of HCC.
|
31239768 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Since first detected in the brain, a number of studies has particularly focused on the role of cav-1 in the various steps of brain tumorigenesis.
|
30993541 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
MiR-107 was involved in HPV-induced tumorigenesis by targeting many genes (CAV1, CDK6, MYB, and SERPINB5) and regulating the p53 signaling pathway, the PI3K-Akt signaling pathway, and the autophagy pathway.
|
31036418 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis.
|
31676993 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The role of Cav-1 in tumorigenesis of breast cancers is relatively less studied.
|
28236153 |
2018 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence.
|
29247004 |
2018 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized.
|
29141593 |
2017 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, Cav-1 may have an important role in the carcinogenesis and progression of HBV-associated HCC and angiogenesis may be affected by Cav-1 during this process.
|
29067114 |
2017 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Herein, we summarize the available evidence of the roles of Cav-1 and oxidative stress in tumorigenesis and development and shed novel light on designing strategies for cancer prevention or treatment by utilizing the interaction mode between Cav-1 and oxidative stress.
|
28546853 |
2017 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We envision that novel targets may come with the further investigation of Cav-1 in carcinogenesis.
|
28243118 |
2017 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Based on the findings, it was concluded that Cav-1 may play a role in the pathogenesis of OLP and carcinogenesis of SCC, but its role in malignant transformation of OLP is not confirmed.
|
28554768 |
2017 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis.
|
27986126 |
2016 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (Cav-1) and Actin-Related Protein 2/3 Complex, Subunit 1B (ARPC1B) have been implicated in various human cancers, yet its role in tumorigenesis remains controversial.
|
26138391 |
2016 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (Cav-1) is a 21 kDa protein enriched in caveolae, and has been implicated in oncogenic cell transformation, tumorigenesis, and metastasis.
|
26065715 |
2015 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Caveolin-1 (Cav-1), a family of ubiquitously expressed oligomeric structural proteins in many mammalian cells, has been shown to be an effective regulator of tumorigenesis.
|
26503358 |
2015 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The RhoA/ROCK pathway and Caveolin-1 (Cav-1) participate in the process of tumorigenesis in numerous types of cancer.
|
26066055 |
2015 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (CAV1) is the main protein in the caveolin family and plays an important role in tumorigenesis signaling.
|
25117072 |
2014 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
CAV-1 is the main structural protein component of caveolae, playing important roles in tumorigenesis and tumor development.
|
24842472 |
2014 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The alteration of caveolin-1 (Cav-1) during carcinogenesis is of great interest and its over-expression in the tumor cell cytoplasm can predict a poor prognosis of renal cell carcinoma (RCC).
|
25246063 |
2014 |
Carcinogenesis
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Our aim was to investigate whether and at which neoplastic stage promoter hypermethylation of CAV1 is involved in human esophageal carcinogenesis.
|
24885118 |
2014 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Increasing evidence suggests that caveolin-1 and large conductance Ca²⁺-activated potassium (BKCa) channels are implicated in the carcinogenesis processes, including cell proliferation and invasion.
|
25397596 |
2014 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Caveolin-1 (Cav-1) is the main protein in the caveolin family and plays a role in tumorigenesis signaling.
|
24778029 |
2014 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues.
|
24939878 |
2014 |