|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Forced expression of WISP3 in HCC cells significantly suppressed cell growth and migration in vitro as well as tumour growth and metastatic seeding in vivo.
|
30793395 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ginsenoside C<sub>3</sub>C<sub>12</sub>PPD suppressed Lewis and A549 tumor growth in vivo without obvious side effects on body weight and the hematology index.
|
31571900 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCN6 recombinant protein reduced IGF2BP2 and HMGA2 protein expression, and decreased growth of MMTV-cre;Ccn6<sup>fl/fl</sup> tumors in vivo.
|
30220054 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, conditional, mammary epithelial-cell specific ccn6 (wisp3) knockout mice develop invasive high-grade mammary carcinomas that recapitulate human spindle cell metaplastic carcinomas, demonstrating a tumor suppressor function for ccn6.
|
29357008 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The optimized nano-formulations demonstrated an appropriate size (~110 nm), high drug loading efficiency (~96.8%) and capacity (~27.9 wt %), long half-time in systemic circulation (nine-fold longer than free PPD), better antitumor effects in vitro and in vivo, higher accumulation at the tumor site and reduced damage to normal tissues.
|
29473838 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas.
|
27819674 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicate that WISP3 harbored not only frameshift mutation but also mutational ITH and loss of expression, which together might play a role in tumorigenesis of GC and CRC with MSI-H by inhibiting tumor suppressor functions of WISP3.
|
26997449 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
During progression of breast cancer, CCN6 protein exerts tumor inhibitory functions.
|
21525039 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using the RT-PCR, we showed the phenotype (WISP3-, RhoC+) is significantly associated with IBC tumors, while the (WISP3+, RhoC-)phenotype is mostly associated to non-IBC tumors.
|
20014943 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
WISP3 functions as a tumor-suppressor gene by modulation of IGF activity and resultant inhibition of cell proliferation, growth, and angiogenesis.
|
19198217 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cysteine-rich protein CCN6 [or Wnt-1-induced signaling protein 3 (WISP3)] exerts tumor-suppressive effects in aggressive inflammatory breast cancer.
|
18321996 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combining 25-OCH3-PPD with conventional chemotherapeutic agents or with radiation led to potent antitumour effects; tumour regression was almost complete following administration of 25-OCH3-PPD and either taxotere or gemcitabine.
|
18253123 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCN6 has tumor growth-, proliferation-, and invasion-inhibitory functions in breast cancer.
|
17587813 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have demonstrated that WISP3 has tumor growth and angiogenesis inhibitory functions in IBC.
|
14696649 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
WISP3 transfection was effective in suppressing in vivo tumor growth in nude mice.
|
12082632 |
2002 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
WISP-3 was mutated in 31% of the MSI-H tumors.
|
11729105 |
2001 |