CD40LG, CD40 ligand, 959

N. diseases: 453; N. variants: 25
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 Biomarker disease BEFREE B cell depletion treatment decreases CD4+IL4+ and CD4+CD40L+ T cells in patients with systemic sclerosis. 31227855 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 Biomarker disease BEFREE Finally, DNA demethylation of regulatory genes (eNOS, CD40L and CD70), therapeutic effects associated with Trichostatin A (TSA) treatment, and abnormal expression of a large spectrum of microRNAs (miR-21, -31, -146, -503, -145, -29b, etc.) are all observed in SSc. 23415078 2013
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 GeneticVariation disease BEFREE Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc. 22731751 2012
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 AlteredExpression disease BEFREE CD40L expression was significantly elevated in female patients with SSc. 22231486 2012