CD40LG, CD40 ligand, 959

N. diseases: 453; N. variants: 25
Disease: Influenza A ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2062441
Disease: Influenza A
Influenza A 		0.020 Biomarker disease BEFREE We generated a recombinant adenovirus (rAd) encoding secreted fusion protein, consisting of codon-optimized HA2 subunit of influenza A/California/7/2009(H1N1) virus fused to a trimerized form of murine CD40L, and determined its ability of inducing protective immunity upon intranasal administration. 25052763 2015
CUI: C2062441
Disease: Influenza A
Influenza A 		0.020 Biomarker disease BEFREE This is typically via CD4(+)CD154(+) T-cell-dependent 'licensing' of CD40(+) dendritic cells (DCs); however, DCs infected with influenza A virus (IAV) upregulate CD154 expression, thus enabling efficient CTL priming in the absence of CD4(+) T activation. 24777309 2014