CARTPT, CART prepropeptide, 9607

N. diseases: 20; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.510 Therapeutic disease CTD_human Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour. 20886038 2010
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.510 Biomarker disease PSYGENET Further studies are needed to evaluate the involvement of CART in other components of the cocaine abuse cycle. 17631364 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.510 Biomarker disease PSYGENET The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse. 10415667 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.340 Biomarker disease PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.340 Biomarker disease PSYGENET Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes. 19254763 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes. 19254763 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.340 Biomarker disease PSYGENET Individuals with a CART mutation display increased anxiety and depression. 18096245 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET Individuals with a CART mutation display increased anxiety and depression. 18096245 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.340 Biomarker disease PSYGENET Adolescents carrying a missense mutation in the CART gene exhibit increased anxiety and depression. 16400624 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.340 Biomarker disease PSYGENET Adolescents carrying a missense mutation in the CART gene exhibit increased anxiety and depression. 16400624 2006
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.340 Biomarker group CTD_human As CART-(55-102) produced anxiety-like effects in rodents, this peptide may possibly be involved in anxiety and stress-related behavior. 12600694 2003
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET Several studies have characterized the role of CART in addiction to psychostimulants, but few have examined the role of CART in alcohol use disorders including alcoholism. 22823101 2014
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Therapeutic disease CTD_human Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour. 20886038 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET Larger peaks (LOD scores >2.0) were typically found in regions previously identified in linkage studies and/or containing proposed candidate genes for alcoholism including AGT, CARTPT, OPRD1, PIK3R1, and PDYN. 19183129 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET Fifth, in humans, CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene associates with alcoholism. 16146347 2005
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET We hypothesized that the polymorphism of CART gene might be related with susceptibility to neuropsychiatric diseases such as alcoholism, bipolar disorder, and schizophrenia. 15234472 2004
CUI: C0236664
Disease: Alcohol-Related Disorders
Alcohol-Related Disorders 		0.300 Biomarker group CTD_human Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice. 22823101 2014
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Therapeutic phenotype CTD_human Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. 21167239 2011