|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better understand the biological traits associated with ulceration that could explain the efficacy of prophylactic type 1 IFN, we performed immunohistochemical analysis of various molecules (major histocompatibility complex class I and class II, MX Dynamin Like GTPase 1 (MX1), inducible Nitric-Oxide Synthase (iNOS) or CD47) in two retrospective cohorts of melanoma patients, one diagnosed with a primary cutaneous melanoma (1995-2013, N = 172, among whom 49% were ulcerated melanoma (UM)) and a second one diagnosed with metastatic melanoma amenable to lymph node resection (EORTC 18952 and 18991 trials, N = 98, among whom 44% were UM).
|
31646109 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, elevated CD47 mRNA expression in human melanomas was associated with improved survival.
|
31362997 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with BRAF/MEK inhibitors upregulated CD47 in cultured melanoma cells and fresh melanoma isolates.
|
29050218 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we aim to study the prognostic value of CD47 in a Chinse melanoma patient cohort and its immunomodulation roles in mouse model.
|
28738534 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protein and gene expression analysis of clinical melanoma samples reveals that CD47, an anti-phagocytic signal, correlates with melanoma metastasis.
|
27477289 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate CD47 as a potential prognostic marker for melanoma development as well as a target for therapeutic intervention with RNAi-based nanomedicines.
|
23774794 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ML-IAP [melanoma IAP (inhibitor of apoptosis)] is an anti-apoptotic protein that is expressed highly in melanomas where it contributes to resistance to apoptotic stimuli.
|
22853455 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
When poly(I:C) is combined to the IAP inhibitor RMT 5265, a cooperative effect in apoptosis induction and/or inhibition of clonogenic growth is obtained in a large fraction of carcinoma and melanoma cell lines.
|
20576118 |
2010 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7,5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML-IAP), and c-IAPs 1 and 2 (cIAP1 and cIAP2).
|
17168540 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether immune-mediated killing of tumor cells can be enhanced by neutralization of IAP proteins, 2 novel eGFP-Smac fusion proteins (pro-Smac) were introduced into the poorly immunogenic mouse melanoma cell line, B16BL6-D5 (D5).
|
14735472 |
2004 |