|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.
|
28736931 |
2018 |
|
response to simvastatin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.
|
28736931 |
2018 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Secondary outcome was overall mean change in MRD1 and the incidence of ptosis as defined by a final MRD1 ≤ 2.5 mm.
|
30908469 |
2020 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Mechanical (involuntary) brow elevation significantly raised MRD1 in control eyelids and eyelids with dermatochalasis, but not in eyelids with ptosis.
|
30124610 |
2019 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
LF and MRD1 had statistically positive correlations in all subtypes of blepharoptosis, in which neurogenic ptosis demonstrated the severest levator dysfunction for each millimeter in MRD1 reduction.
|
30877447 |
2019 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Both external levator resection (ELR) and Müller's muscle-conjunctival resection (MMCR) are procedures well known to improve marginal reflex distance (MRD1) in patients with ptosis.
|
29799019 |
2018 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
The frequency of true blepharoptosis (MRD1 ≤ 2.0 mm) was 24 of 95 (25.3%) in the unilateral involutional entropion group and was even higher in the bilateral involutional lower eyelid entropion group, with 7 of 16 (43.8%) patients exhibiting bilateral blepharoptosis.
|
29342029 |
2018 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
The Volk device measures MRD1 well in normal patients but overestimates MRD1 in patients with ptosis.
|
28863120 |
2018 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
This study examined patient sex and age, preoperative LF, margin reflex distance of the upper eyelid (MRD1), and ptosis severity.
|
28195895 |
2017 |
|
Blepharoptosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Hypertension, diabetes, higher body mass index (BMI), and lower education had statistically significant association with blepharoptosis adjusting all other confounders.ConclusionsThe distribution and proportional changes of levator function and marginal reflex distance 1 (MRD1) with aging implicate a contributory role of muscular degeneration.
|
28338663 |
2017 |
|
Blepharoptosis
|
0.090 |
Biomarker
|
disease |
BEFREE |
MRD1 decreased in the contralateral eye in IB patients, significantly more so after the phenylephrine test: PE vs. ME = 18.9% versus 17.2% reduction in the unilateral group, and 13.6% versus 10.7% reduction in the bilateral group.
|
26148340 |
2017 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Secondary outcome was overall mean change in MRD1 and the incidence of ptosis as defined by a final MRD1 ≤ 2.5 mm.
|
30908469 |
2020 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
LF and MRD1 had statistically positive correlations in all subtypes of blepharoptosis, in which neurogenic ptosis demonstrated the severest levator dysfunction for each millimeter in MRD1 reduction.
|
30877447 |
2019 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Mechanical (involuntary) brow elevation significantly raised MRD1 in control eyelids and eyelids with dermatochalasis, but not in eyelids with ptosis.
|
30124610 |
2019 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
The Volk device measures MRD1 well in normal patients but overestimates MRD1 in patients with ptosis.
|
28863120 |
2018 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Both external levator resection (ELR) and Müller's muscle-conjunctival resection (MMCR) are procedures well known to improve marginal reflex distance (MRD1) in patients with ptosis.
|
29799019 |
2018 |
|
Ptosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
This study examined patient sex and age, preoperative LF, margin reflex distance of the upper eyelid (MRD1), and ptosis severity.
|
28195895 |
2017 |
|
Lagophthalmos
|
0.030 |
Biomarker
|
disease |
BEFREE |
Primary outcome measures included lagophthalmos on blink, gentle and forced eyelid closure, upper eyelid margin to reflex distance (MRD1), corneal staining, static and dynamic validated scoring for facial palsy patients and complications.
|
31765627 |
2019 |
|
Lagophthalmos
|
0.030 |
Biomarker
|
disease |
BEFREE |
Intraoperative lagophthalmos in patients with satisfactory surgical outcome correlated negatively with both preoperative MRD1 and levator function and accounting for both variables resulted in a stronger correlation than either variable alone.
|
30049800 |
2019 |
|
Lagophthalmos
|
0.030 |
Biomarker
|
disease |
BEFREE |
The patients were treated with subconjunctival triamcinolone acetonide injections monthly and evaluated pre- and post-treatment by taking measurements of the upper margin reflex distance (MRD1, the distance between the upper-lid margin and the pupil center), lid aperture, lagophthalmos and proptosis.
|
30140631 |
2018 |
|
Neoplasm, Residual
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Both MRD0+/MRD1+ and MRD0+/MRD1- patients had a significantly worse EFS (p = 0.0001) than those with undetectable MRD at both MRD0 and MRD1.
|
26449287 |
2017 |
|
Neoplasm, Residual
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Forty-four patients turned MRD negative 1 month after Chemo-DLI; their cumulative incidences of relapse and DFS were significantly better than those with persistent MRD 1 month after preemptive Chemo-DLI (relapse: 19.8% vs. 46.8%, P = 0.001; DFS: 69.6% vs. 46.4%, P = 0.004).
|
26010204 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SNHG7 induces the development of cisplatin-resistance in NSCLC through upregulating MRD1 and BCRP via PI3K/AKT pathway.
|
31486493 |
2019 |
|
Cutis Laxa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanical (involuntary) brow elevation significantly raised MRD1 in control eyelids and eyelids with dermatochalasis, but not in eyelids with ptosis.
|
30124610 |
2019 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conversely, MRD1 was lower in oGVHD patients compared to controls (p < 0.001).
|
30321606 |
2019 |