|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.830 |
GeneticVariation |
GWASCAT |
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
|
29358691 |
2018 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.830 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that the rs340874 single nucleotide polymorphism (SNP) in PROX1 is a genetic susceptibility factor for type 2 diabetes.
|
23274905 |
2013 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation |
BEFREE |
We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively).
|
22992776 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation |
BEFREE |
Further adjusting age, gender and BMI as confounders found PROX1 rs340874 was associated with type 2 diabetes (p = 0.0391).
|
21103350 |
2010 |
|
rs340874
|
PROX1;PROX1-AS1
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation |
GWASCAT |
Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.
|
31021400 |
2019 |
|
rs2075423
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs2075423
|
PROX1;PROX1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Body mass index
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation |
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Body mass index
|
T |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Fasting blood glucose measurement
|
T |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
22581228 |
2012 |
|
rs340874
|
PROX1;PROX1-AS1
|
Fasting blood glucose measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
20081858 |
2010 |
|
rs4342822
|
PROX1-AS1;LOC105372912
|
Breast Carcinoma
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Among survivors who received 10 or higher gray breast radiation exposure, a locus on 1q41 was associated with subsequent breast cancer risk (rs4342822, nearest gene PROX1 , risk allele frequency in control subjects [RAF controls ] = 0.46, hazard ratio = 1.92, 95% confidence interval = 1.49 to 2.44, P = 7.09 × 10 -9 ).
|
29059430 |
2017 |
|
rs4342822
|
PROX1-AS1;LOC105372912
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation |
BEFREE |
Among survivors who received 10 or higher gray breast radiation exposure, a locus on 1q41 was associated with subsequent breast cancer risk (rs4342822, nearest gene PROX1 , risk allele frequency in control subjects [RAF controls ] = 0.46, hazard ratio = 1.92, 95% confidence interval = 1.49 to 2.44, P = 7.09 × 10 -9 ).
|
29059430 |
2017 |
|
rs7529073
|
PROX1-AS1
|
Schizophrenia
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
rs115732928
|
PROX1-AS1
|
Astigmatism
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.
|
30306274 |
2018 |
|
rs4342822
|
PROX1-AS1;LOC105372912
|
Malignant Childhood Neoplasm
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.
|
29059430 |
2017 |
|
rs7529073
|
PROX1-AS1
|
Schizophrenia
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
|
28991256 |
2017 |
|
rs79687284
|
PROX1-AS1
|
Fasting blood glucose measurement
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
|
28270201 |
2017 |
|
rs182234674
|
PROX1-AS1
|
response to bronchodilator
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
rs340839
|
PROX1;PROX1-AS1
|
Triglycerides measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
The impact of low-frequency and rare variants on lipid levels.
|
25961943 |
2015 |