NOTCH4, notch receptor 4, 4855

N. diseases: 24; N. variants: 38
Source: GWASDB ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2071277
rs2071277
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0242383
Disease:
Age related macular degeneration 		C 0.810 GeneticVariation GWASDB Using a replication sample of 1411 advanced AMD cases and 1431 examined controls, we confirmed a novel association between AMD and single-nucleotide polymorphisms on chromosome 6p21.3 at TNXB (tenascin XB)-FKBPL (FK506 binding protein like) [rs12153855/rs9391734; discovery P =4.3 × 10(-7), replication P =3.0 × 10(-4), combined P =1.3 × 10(-9), odds ratio (OR) = 1.4, 95% confidence interval (CI) = 1.3-1.6] and the neighbouring gene NOTCH4 (Notch 4) (rs2071277; discovery P =3.2 × 10(-8), replication P =3.8 × 10(-5), combined P =2.0 × 10(-11), OR = 1.3, 95% CI = 1.2-1.4). 22694956 2012
dbSNP: rs3131296
rs3131296
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036341
Disease:
Schizophrenia 		0.810 GeneticVariation GWASDB Common variants at VRK2 and TCF4 conferring risk of schizophrenia. 21791550 2011
dbSNP: rs404860
rs404860
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0004096
Disease:
Asthma 		A 0.810 GeneticVariation GWASDB We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10(-23)), which is close to rs2070600, a SNP previously reported for association with FEV(1)/FVC in genome-wide association studies for lung function. 21804548 2011
dbSNP: rs3131296
rs3131296
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036341
Disease:
Schizophrenia 		G 0.810 GeneticVariation GWASDB Common variants conferring risk of schizophrenia. 19571808 2009
dbSNP: rs3132935
rs3132935
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036341
Disease:
Schizophrenia 		0.800 GeneticVariation GWASDB A comprehensive family-based replication study of schizophrenia genes. 23894747 2013
dbSNP: rs3134931
rs3134931
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C2698399
Disease:
Myeloperoxidase Measurement 		T 0.800 GeneticVariation GWASDB Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. 23620142 2013
dbSNP: rs2071278
rs2071278
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0577608
Disease:
C4 complement assay (procedure) 		G 0.800 GeneticVariation GWASDB Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. 23028341 2012
dbSNP: rs443198
rs443198
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036421
Disease:
Systemic Scleroderma 		0.800 GeneticVariation GWASDB Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. 21779181 2011
dbSNP: rs443198
rs443198
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036421
Disease:
Systemic Scleroderma 		0.800 GeneticVariation GWASDB Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
dbSNP: rs715299
rs715299
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0036202
Disease:
Sarcoidosis 		0.710 GeneticVariation GWASDB Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. 22952805 2012
dbSNP: rs3131296
rs3131296
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		T 0.700 GeneticVariation GWASDB GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2014
dbSNP: rs3134942
rs3134942
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		T 0.700 GeneticVariation GWASDB GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2014
dbSNP: rs3096702
rs3096702
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		A 0.700 GeneticVariation GWASDB Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. 23535732 2013
dbSNP: rs391755
rs391755
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C1527304
Disease:
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs397081
rs397081
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C1527304
Disease:
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs13215567
rs13215567
Entrez Id: 4855;63940
Gene Symbol: NOTCH4;GPSM3
NOTCH4;GPSM3
CUI: C0162701
Disease:
Polysomnography 		A 0.700 GeneticVariation GWASDB Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
dbSNP: rs2071286
rs2071286
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0030809
Disease:
Pemphigus Vulgaris 		0.700 GeneticVariation GWASDB Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. 22437316 2012
dbSNP: rs3131296
rs3131296
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0026896
Disease:
Myasthenia Gravis 		0.700 GeneticVariation GWASDB Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. 23055271 2012
dbSNP: rs3134942
rs3134942
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0242379
Disease:
Malignant neoplasm of lung 		0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653 2012
dbSNP: rs422951
rs422951
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0242383
Disease:
Age related macular degeneration 		0.700 GeneticVariation GWASDB Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. 22694956 2012
dbSNP: rs443198
rs443198
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0030809
Disease:
Pemphigus Vulgaris 		0.700 GeneticVariation GWASDB Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. 22437316 2012
dbSNP: rs206015
rs206015
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.700 GeneticVariation GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
dbSNP: rs206016
rs206016
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.700 GeneticVariation GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
dbSNP: rs2071278
rs2071278
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.700 GeneticVariation GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
dbSNP: rs2071285
rs2071285
Entrez Id: 4855
Gene Symbol: NOTCH4
NOTCH4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.700 GeneticVariation GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011