LEF1, lymphoid enhancer binding factor 1, 51176

N. diseases: 211; N. variants: 13
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2003869
rs2003869
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		G 0.800 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 26956414 2016
dbSNP: rs2003869
rs2003869
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		G 0.800 GeneticVariation GWASDB Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs898518
rs898518
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		A 0.800 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs898518
rs898518
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		A 0.800 GeneticVariation GWASDB Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs67372037
rs67372037
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs7668764
rs7668764
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs116711774
rs116711774
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0018498
Disease:
Hair Color 		0.700 GeneticVariation GWASCAT Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability. 30531825 2018
dbSNP: rs922168
rs922168
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0018498
Disease:
Hair Color 		0.700 GeneticVariation GWASCAT Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability. 30531825 2018
dbSNP: rs7665304
rs7665304
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs7665304
rs7665304
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs7690934
rs7690934
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		C 0.700 GeneticVariation GWASCAT Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. 28165464 2017
dbSNP: rs7690934
rs7690934
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		C 0.700 GeneticVariation GWASCAT Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. 28165464 2017
dbSNP: rs2003869
rs2003869
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		G 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 26956414 2016
dbSNP: rs898518
rs898518
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		A 0.700 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs369649181
rs369649181
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.700 GeneticVariation UNIPROT
dbSNP: rs76996680
rs76996680
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023449
Disease:
Acute lymphocytic leukemia 		0.010 GeneticVariation BEFREE We identified 2 novel LEF1 mutations (K86E and P106L) in 4 of 131 patients with ALL, and those patients with high-risk ALL (high WBC, complex karyotype). 25942645 2015
dbSNP: rs76996680
rs76996680
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0751606
Disease:
Adult Acute Lymphocytic Leukemia 		0.010 GeneticVariation BEFREE We identified 2 novel LEF1 mutations (K86E and P106L) in 4 of 131 patients with ALL, and those patients with high-risk ALL (high WBC, complex karyotype). 25942645 2015
dbSNP: rs76996680
rs76996680
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0023452
Disease:
Childhood Acute Lymphoblastic Leukemia 		0.010 GeneticVariation BEFREE We identified 2 novel LEF1 mutations (K86E and P106L) in 4 of 131 patients with ALL, and those patients with high-risk ALL (high WBC, complex karyotype). 25942645 2015
dbSNP: rs1048060629
rs1048060629
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C4085595
Disease:
AL-RAQAD SYNDROME 		0.010 GeneticVariation BEFREE The PITX2 T68P ARS mutant protein physically interacts with FoxJ1; however, it cannot activate the FoxJ1 promoter. 18723525 2008
dbSNP: rs61752607
rs61752607
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0018213
Disease:
Graves Disease 		0.010 GeneticVariation BEFREE In this study, we evaluated the A/G(-1661), C/T(-318), A/G49 and A/G6230 single nucleotide polymorphisms (SNPs) of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene for association with Graves' disease (GD) in 126 Russian simplex families. 16297665 2006
dbSNP: rs769814612
rs769814612
Entrez Id: 51176;641518
Gene Symbol: LEF1;LEF1-AS1
LEF1;LEF1-AS1
CUI: C0018213
Disease:
Graves Disease 		0.010 GeneticVariation BEFREE In this study, we evaluated the A/G(-1661), C/T(-318), A/G49 and A/G6230 single nucleotide polymorphisms (SNPs) of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene for association with Graves' disease (GD) in 126 Russian simplex families. 16297665 2006