rs4689388
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
A
0.820
GeneticVariation
GWASCAT
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
28869590
2017
rs4689388
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.820
GeneticVariation
BEFREE
A recent T2D GWAS revealed an association signal (rs4689388 ) upstream of the gene encoding Wolfram syndrome 1 (WFS1) whose intrinsic nucleotide variants had been previously associated with T2D in several candidate gene analyses.
25800097
2016
rs4689388
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.820
GeneticVariation
BEFREE
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
23144361
2012
rs4689388
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.820
GeneticVariation
GWASDB
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
21647700
2011
rs4689388
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
T
0.820
GeneticVariation
GWASCAT
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
19734900
2009
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
C
0.810
GeneticVariation
GWASCAT
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
30054458
2018
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.810
GeneticVariation
GWASDB
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
23300278
2013
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.810
GeneticVariation
GWASDB
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
22885922
2012
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
T
0.810
GeneticVariation
GWASCAT
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
22885922
2012
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.810
GeneticVariation
BEFREE
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214 ), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
23144361
2012
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
T
0.810
GeneticVariation
GWASCAT
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
20581827
2010
rs1801214
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
T
0.810
GeneticVariation
GWASDB
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
20581827
2010
rs104893882
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.
25388789
2014
rs104893882
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
WFS1 and non-syndromic low-frequency sensorineural hearing loss: a novel mutation in a Portuguese case.
24462758
2014
rs104893883
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
WFS1 and non-syndromic low-frequency sensorineural hearing loss: a novel mutation in a Portuguese case.
24462758
2014
rs104893883
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.
25388789
2014
rs4458523
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
G
0.800
GeneticVariation
GWASDB
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
24509480
2014
rs4458523
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
G
0.800
GeneticVariation
GWASCAT
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
24509480
2014
rs372855769
WFS1;LOC107986257
Wolfram Syndrome 1
0.800
GeneticVariation
UNIPROT
Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease.
22226368
2012
rs4458523
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
G
0.800
GeneticVariation
GWASCAT
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
22885922
2012
rs4458523
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.800
GeneticVariation
GWASDB
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
22885922
2012
rs104893882
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss.
21356526
2011
rs104893883
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
DEAFNESS, AUTOSOMAL DOMINANT 6
0.800
GeneticVariation
UNIPROT
Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss.
21356526
2011
rs372855769
WFS1;LOC107986257
Wolfram Syndrome 1
0.800
GeneticVariation
UNIPROT
Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment.
21538838
2011
rs387906930
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Wolfram-Like Syndrome, Autosomal Dominant
0.800
GeneticVariation
UNIPROT
Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment.
21538838
2011