CLOCK, clock circadian regulator, 9575

N. diseases: 309; N. variants: 31
Disease: Mental Depression ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11932595
rs11932595
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0011570
Disease:
Mental Depression 		0.020 GeneticVariation BEFREE In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028). 30728411 2019
dbSNP: rs1801260
rs1801260
Entrez Id: 9575;55858
Gene Symbol: CLOCK;TMEM165
CLOCK;TMEM165
CUI: C0011570
Disease:
Mental Depression 		0.020 GeneticVariation BEFREE In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028). 30728411 2019
dbSNP: rs11932595
rs11932595
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0011570
Disease:
Mental Depression 		0.020 GeneticVariation BEFREE In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243). 24673294 2014
dbSNP: rs1801260
rs1801260
Entrez Id: 9575;55858
Gene Symbol: CLOCK;TMEM165
CLOCK;TMEM165
CUI: C0011570
Disease:
Mental Depression 		0.020 GeneticVariation BEFREE Our meta-analysis shows no association between rs1801260 and mood disorders (as a complete phenotype) or depression severity and points out the necessity of further research in order to better understand the underlying biological machinery of circadian dysfunction in subjects affected by mood disorders. 20560707 2010
dbSNP: rs4580704
rs4580704
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0011570
Disease:
Mental Depression 		0.010 GeneticVariation BEFREE In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028). 30728411 2019