CLOCK, clock circadian regulator, 9575

N. diseases: 309; N. variants: 31
Disease: Hypertensive disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1554483
rs1554483
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE A significant interaction between the 5-HTTLPR variant and the haplotype rs1554483-rs4864548 of the CLOCK gene was detected for diastolic (p = .0058) and systolic blood pressure (p = .0014), arterial hypertension (p = .033), plasma triglycerides levels (p = .033), and number of MS components (p = .01). 20653450 2010
dbSNP: rs4864548
rs4864548
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE A significant interaction between the 5-HTTLPR variant and the haplotype rs1554483-rs4864548 of the CLOCK gene was detected for diastolic (p = .0058) and systolic blood pressure (p = .0014), arterial hypertension (p = .033), plasma triglycerides levels (p = .033), and number of MS components (p = .01). 20653450 2010
dbSNP: rs4580704
rs4580704
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE For single nucleotide polymorphism rs4580704, minor allele carriers had a 46% lower risk of hypertension than did noncarriers. 19846548 2009