Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The p.V600E mutation in the BRAF protein is the most frequent mutation in cutaneous melanoma and is a recurrent alteration found in common benign naevi.
|
31102256 |
2020 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
A total of 46 adult lymph node-positive primary skin melanoma patients (23 BRAF-mutant and 23 BRAF-wild) with available information on the mutational status of the oncogene BRAF V600E were included in the analysis.
|
30997532 |
2019 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Additionally, an analysis of the correlation network reconstructed using TCGA-SKCM emphasized KMO and KYNU with high variability among BRAF wild-type compared with V600E, which underscored their role in distinct CD4+ T-cell behavior in tumour immunity.
|
31434983 |
2019 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
BRAF inhibitors target the BRAF-V600E/K mutated kinase, the driver mutation found in 50% of cutaneous melanoma.
|
30429474 |
2018 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Clinical significance of BRAF V600E mutational status in capsular nevi of sentinel lymph nodes in patients with primary cutaneous melanoma.
|
27666765 |
2017 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy.
|
29310328 |
2017 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Putative genomic characteristics of BRAF V600K versus V600E cutaneous melanoma.
|
28858076 |
2017 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The BRAF V600E mutation accounts for the majority of BRAF mutations found in cutaneous melanoma and is also commonly found in nevi.
|
25607474 |
2015 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We investigated 132 cases of primary cutaneous melanoma in patients aged between 18 and 30 years with emphasis on clinical characteristics, pathologic features, and molecular evaluation of mutation in the BRAF gene (BRAF(V600E)).
|
24471189 |
2014 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues.
|
24858900 |
2014 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The present study investigated the BRAF V600E mutation frequency and its clinical implications in a group of 77 primary cutaneous melanoma patients treated in a cancer reference center in Brazil.
|
24535907 |
2014 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Tumor microenvironment greatly differs between visceral metastasis and primary cutaneous melanoma, and the mechanisms involved in the antimetastatic efficacy of BRAF(V600E) inhibitors remain to be determined.
|
25351955 |
2014 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We obtained blood and tissue samples from a patient diagnosed with a BRAF(V600E)-mutant cutaneous melanoma that was treated with vemurafenib and achieved a near-complete response.
|
23948972 |
2013 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Patients diagnosed with BRAF V600E mutated cutaneous melanoma show response to treatment with the BRAF inhibitor Vemurafenib.
|
23159593 |
2013 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
BRAF(V600E) is the most common mutation in cutaneous melanoma and has become the target of treatment for patients with metastatic melanoma.
|
23211290 |
2013 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The most common recurring mutation in cutaneous melanoma is the prooncogenic BRAF V600E mutation that drives melanoma cell proliferation.
|
23174497 |
2012 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The effect of NRAS mutations on the pathological features and clinical outcomes in patients with cutaneous melanoma was compared with that of tumors containing BRAF(V600E) mutations and tumors wild type for both (WT).
|
21615881 |
2011 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The classical V600E BRAF mutation was not found; instead a novel V600L was observed suggesting that the oncogenic event in OMM is different from that in skin melanoma.
|
21750866 |
2011 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We propose an assay based on the use of a locked nucleic acid probe and an allele specific primer to measure plasma-circulating BRAF(V600E) concentration in patients affected by cutaneous melanoma (n=55) and non-melanoma skin cancers (n=13) as well as 18 healthy subjects.
|
20576522 |
2010 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.
|
15935100 |
2005 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine whether the T1799A BRAF mutation found in cutaneous melanoma is also present in conjunctival melanoma.
|
15277467 |
2004 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
With regard to the frequency of V599E BRAF mutations, AM significantly differs from CM (P < or = .0001), which suggests that BRAF mutations distinguish anorectal from cutaneous melanoma at the molecular level.
|
15578519 |
2004 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The most common mutation, occurring in 80% of cutaneous melanoma samples, is a T-to-A transition resulting in a single amino acid substitution (V599E).
|
15179189 |
2004 |
Cutaneous Melanoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The activating V599E mutation accounted for 80% of all mutations detected in cutaneous melanoma cell lines.
|
12917419 |
2003 |