|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear.
|
22286212 |
2012 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
In contrast, the lack of any association between rs20541 (IL13) and psoriasis in our Egyptian cohort suggests the existence of important inter-ethnic genetic differences in psoriasis susceptibility.
|
25406098 |
2015 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
The authors genotyped three groups of Caucasians: those with PsA, those with psoriasis without arthritis (PsC) and healthy controls for the rs20541 and rs848 IL13 single nucleotide polymorphisms (SNPs).
|
21613309 |
2011 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
In subgroup analyses, the two SNPs were significantly associated (P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients.
|
23617596 |
2013 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
The minor allele T of rs20541 in IL13 is the risk allele for asthma but the protective allele for psoriasis.
|
22694930 |
2012 |
|
Hodgkin Disease
|
|
0.810 |
GeneticVariation
|
BEFREE |
We searched for an association between the interleukin 4 receptor gene (IL4R) rs1805015 and interleukin 13 gene (IL13) rs20541 polymorphisms and the development of antibodies to hepatitis B surface antigen (anti-HBs) in the case of hepatitis B virus (HBV) vaccination or infection in hemodialysis (HD) patients.
|
23462527 |
2013 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
|
28273659 |
2017 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear.
|
22286212 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
ICSNPathway analysis identified four candidate causal SNPs, four genes, and 21 candidate causal pathways, which in total provided four hypothetical biologic mechanisms: (1) rs7192 (nonsynonymous coding) to HLA-DRA to 21 pathways, such as, the role of eosinophils in the chemokine network of allergy, Th1/Th2 differentiation, and asthma (nominal p ≤ 0.001, FDR p ≤ 0.01); (2) rs20541 (nonsynonymous coding) to IL13 to asthma and cytokines and inflammatory response (nominal p<0.001, FDR p ≤ 0.008); (3) rs1058808 (frameshift coding) to ERBB2 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01); (4) rs17350764 (nonsynonymous coding (deleterious)) to OR52J3 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01).
|
23200760 |
2013 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide polymorphisms (SNPs) from eight candidate genes (IL-4 rs2243250, IL-4Rα rs1805010, IL-13 rs20541, IL-13Rα1 rs2495636, CD14 rs2569190, tumor necrosis factor-alpha (TNF-α) rs1800629, cytotoxic T lymphocyte-associated antigen (CTLA4) rs231775, FCER1B rs1441585) in children with asthma and to evaluate gene-gene interactions.
|
22376040 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These results support the existence of a significant association between GSTP1 rs1695 and IL13 rs20541 SNPs, with susceptibility to asthma, in the population studied.
|
27561723 |
2018 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses.
|
22222605 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population.
|
29211635 |
2018 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations.
|
20484924 |
2010 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The minor allele T of rs20541 in IL13 is the risk allele for asthma but the protective allele for psoriasis.
|
22694930 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
|
28273659 |
2017 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.
|
23954258 |
2013 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Gene-environment interactions between IL-13 (rs20541) and antibiotics or mold may play a role in AR.
|
24973272 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians.
|
29687183 |
2018 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis.
|
22023794 |
2011 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
When stratifying for race, IL-13 SNP rs20541 exhibited increased AR risk in Asians (Gln versus Arg: OR=1.20, 95% CI=1.06-1.36; Gln/Gln versus Arg/Arg: OR=1.57, 95% CI=1.17-2.12; Arg/Gln+Gln/Gln versus Arg/Arg: OR=1.22, 95% CI=1.04-1.44; Gln/Gln versus Arg/Gln+Arg/Arg: OR=1.45, 95% CI=1.09-1.93), while no significant association was detected in Caucasians (Gln versus Arg: OR=1.28, 95% CI=0.93~1.78; Gln/Gln versus Arg/Arg: OR=1.42, 95% CI=0.96-2.11; Arg/Gln+Gln/Gln versus Arg/Arg: OR=1.35, 95% CI=0.89-2.05; Gln/Gln versus Arg/Gln+Arg/Arg: OR=1.37, 95% CI=0.93-2.02).
|
23545317 |
2013 |