|
ALLERGIC RHINITIS, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
ASTHMA, SUSCEPTIBILITY TO (finding)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Kaposi's sarcoma classical type
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with controls, CKS risk was decreased with 1235T/-1010G-containing diplotypes of IL8RB (odds ratio, 0.49; 95% confidence interval, 0.30-0.78; P = 0.003), whereas risk was increased with diplotypes of IL13 containing the promoter region variant 98A (rs20541, alias +130; odds ratio, 1.88; 95% confidence interval, 1.15-3.08; P = 0.01) when considered in multivariate analysis.
|
16702372 |
2006 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (OR(AG/AA) = 0.62,95% CI = 0.44-0.87, p = 0.006), as was vascular cell adhesion molecule-1, VCAM1 Ex9+149G>A SNP (rs1041163) (OR(CT) = 0.77, 95% CI = 0.54-1.10, OR(CC) = 0.35, 95% CI = 0.16-0.76, p-trend = 0.007).
|
19533685 |
2009 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
Wheezing
|
|
0.020 |
GeneticVariation
|
BEFREE |
There was a statistically significant association between the IL-13 Arg144Gln polymorphism and risk of recurrent wheeze (p = 0.01).
|
19674346 |
2009 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
IL13 SNPs rs2066960(intron 1), rs20541(R130Q) and rs1295685(exon 4) were associated with COPD risk and lower baseline lung function in the recessive model.
|
19796199 |
2010 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively).
|
20406895 |
2010 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations.
|
20484924 |
2010 |
|
Small Lymphocytic Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
Marginal Zone B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
GWASDB |
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
|
20953187 |
2010 |
|
Eczema
|
|
0.030 |
GeneticVariation
|
BEFREE |
The significant association of the rs20541 SNP with eczema essentially disappeared after additional adjustment for the rs1800925 SNP, whereas a relationship with the rs1800925 SNP remained significant.
|
20975284 |
2011 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
We conclude that there is evidence for an overall association between IL13 SNP rs20541 and increased risk of AR, especially in mixed-age populations.
|
21309855 |
2011 |
|
Arthritis, Psoriatic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
Psoriasis vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
Psoriasis
|
|
0.860 |
GeneticVariation
|
BEFREE |
The authors genotyped three groups of Caucasians: those with PsA, those with psoriasis without arthritis (PsC) and healthy controls for the rs20541 and rs848 IL13 single nucleotide polymorphisms (SNPs).
|
21613309 |
2011 |
|
Arthritis, Psoriatic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The authors genotyped three groups of Caucasians: those with PsA, those with psoriasis without arthritis (PsC) and healthy controls for the rs20541 and rs848 IL13 single nucleotide polymorphisms (SNPs).
|
21613309 |
2011 |