|
Osteoporosis, Postmenopausal
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Results:</b><i>P2X7R</i> rs2230911 was found to be associated with serum total cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein, and BMD at the lumbar spine and hip in OP patients (<i>p</i> < 0.05).
|
31079509 |
2019 |
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
Primary gout
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results reveal that P2RX7 rs2230911 may be associated with primary gout</span> risk in a Chinese Han male population and allele G may be a susceptibility factor for primary gout.
|
28243797 |
2017 |
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results showed that rs3751143 was associated with OP; in particular, carriers of the C allele and CC/(AC + CC) genotypes were at a higher risk of OP, but no significant association of rs2230911, rs7958311, rs1718119, and rs2393799 with OP risk was observed.
|
28497417 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results showed that rs1718119 was associated with SLE; in particular carriers of the A allele and AA/AG/(AG+AA) genotypes were at lower risk of the disease [A versus G, P < 0.001, odds ratio (OR) = 0.543, 95% CI: 0.424-0.697; AG versus GG, P = 0.018, OR = 0.659, 95% CI: 0.466-0.931; AA versus GG, P = 0.011, OR = 0.176, 95% CI: 0.046-0.668; AG+AA versus GG, P = 0.004, OR = 0.607, 95% CI: 0.433-0.850], but no significant differences in rs2230911 and rs3751143 were observed between SLE patients and controls.
|
23435013 |
2013 |
|
Nephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification of cases for the presence of nephritis showed that rs2230911 G allele and CG/(CG+GG) genotypes were at a lower risk of SLE with nephritis (LN) (G versus C, P = 0.011, OR = 0.640, 95% CI: 0.454-0.903; CG versus CC, P = 0.035, OR = 0.645, 95% CI: 0.429-0.970; GG versus CC, P = 0.101, OR = 0.349, 95% CI: 0.099-1.228; CG+GG versus CC, P = 0.015 OR = 0.612, 95% CI: 0.411-0.910), but rs1718119 and rs3751143 were not associated with LN.
|
23435013 |
2013 |