|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
|
30805717 |
2019 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors.
|
28973302 |
2017 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry.
|
25633098 |
2016 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
The CLU haplotypes AA+GA (odds ratio (OR) = 4.483; 95% CI: 1.069-18.792) of rs2279590 was correlated with AD.
|
26757186 |
2016 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Our results showed significant association between rs2279590 polymorphism and AD in Asian population with P = 2.00E-04 and P = 2.00E-04 using additive and recessive models, respectively.
|
24947876 |
2015 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
Alzheimer's Disease
|
|
0.840 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we aimed to investigate the functional significance of a clusterin intronic SNP, rs2279590, that has been associated with pseudoexfoliation, Alzheimer's disease (AD) and diabetes.
|
28973302 |
2017 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we aimed to investigate the functional significance of a clusterin intronic SNP, rs2279590, that has been associated with pseudoexfoliation, Alzheimer's disease (AD) and diabetes.
|
28973302 |
2017 |
|
Amyloidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, four loci (rs11136000, rs1532278, rs2279590, rs7982) showed significant associations with the Aβ deposition at the baseline level while genotypes of rs9331888 (P = 0.042) increased Aβ deposition.
|
27229352 |
2016 |
|
Exfoliation Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association between rs2279590 and XFS was also found in Indian populations (summary OR = 0.76, 95% CI: 0.61-0.96; P = 0.02); however, significant heterogeneity between the Caucasian and Indian populations possibly due to reversal of the risk allele precluded an overall meta-analysis for rs2279590 (Q = 0.001, I(2) = 91%).
|
26272660 |
2015 |