|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
|
30111768 |
2018 |
|
P-Selectin Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Connecting genetic risk to disease end points through the human blood plasma proteome.
|
28240269 |
2017 |
|
Soluble P-Selectin Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
|
20167578 |
2010 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggested there is an increase in the risk of CAD conferred by the Ser128Arg polymorphism and the thr715Pro polymorphism may be a protective factor of MI.
|
24498435 |
2014 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
PSEL S290N, in single polymorphism analysis and in the haplotypic background with T715P, was associated with increased risk of incident CHD in whites.
|
17420019 |
2007 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The P-selectin Thr715Pro polymorphism is not associated with incident CHD or ischemic stroke in either whites or African-Americans.
|
16125711 |
2006 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.
|
16125711 |
2006 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We measured serum soluble P-selectin levels as well as 3 polymorphisms of the P-selectin gene (C-2123G, A-1969G, and Thr715Pro) in a large cohort of patients with documented coronary artery disease (n=869) and a healthy control group (n=334).
|
11597943 |
2001 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We measured serum soluble P-selectin levels as well as 3 polymorphisms of the P-selectin gene (C-2123G, A-1969G, and Thr715Pro) in a large cohort of patients with documented coronary artery disease (n=869) and a healthy control group (n=334).
|
11597943 |
2001 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs1800805, rs6136 minor allele of SELP gene, rs1800796 within IL-6 gene, and additional interaction between rs1800805 and rs1800796 with increased risk of CVD.
|
28819827 |
2017 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggested there is an increase in the risk of CAD conferred by the Ser128Arg polymorphism and the thr715Pro polymorphism may be a protective factor of MI.
|
24498435 |
2014 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
We analyzed single nucleotide polymorphisms of P-selectin gene -2,123 G/C, -1,969 G/A, -1,817 T/C and Thr715Pro in three hundred and five patients with ischemic stroke and 280 age and sex matched controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method.
|
18034324 |
2009 |
|
Venous Thromboembolism
|
|
0.020 |
GeneticVariation
|
BEFREE |
We assessed the effect of four single nucleotide polymorphisms (SNPs) [one in the promoter region (c.-2123C>G) and three (S290N, c.1087G>A; D562N, c.1902G>A; T715P, c.2363A>C) in the coding region] and the calculated haplotypes in the P-selectin gene (SELP) on sP-selectin concentrations and VTE risk.
|
18449419 |
2008 |
|
Venous Thromboembolism
|
|
0.020 |
GeneticVariation
|
BEFREE |
The effect on venous thromboembolism (VTE) of increased circulating concentrations of soluble P-selectin (sP-selectin) and their association with the P-selectin variant Thr715Pro is still uncertain.
|
17510305 |
2007 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Several studies have attempted to demonstrate the association of the most intensively examined variant of P-selectin gene polymorphism (Thr715Pro) with sP-selectin levels in healthy subjects and in CVD, but contradictory data have been reported.
|
17598012 |
2007 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The P-selectin Thr715Pro polymorphism is not associated with incident CHD or ischemic stroke in either whites or African-Americans.
|
16125711 |
2006 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.
|
16125711 |
2006 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
These polymorphisms were tested individually for association with myocardial infarction (MI) and only the T715P polymorphism was shown to be associated with MI.
|
12165563 |
2002 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We measured serum soluble P-selectin levels as well as 3 polymorphisms of the P-selectin gene (C-2123G, A-1969G, and Thr715Pro) in a large cohort of patients with documented coronary artery disease (n=869) and a healthy control group (n=334).
|
11597943 |
2001 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, we found SELP rs6136-T to be associated with RA and with increased expression of SELP mRNA.
|
25147926 |
2014 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here we investigated the prognostic value and association of SELP-rs6136, IL6-rs1800796 and AKT1-rs1130233 polymorphisms with cachexia in PDAC.
|
25238546 |
2014 |
|
Cachexia
|
|
0.010 |
GeneticVariation
|
BEFREE |
SELP-rs6136-AA and AKT1-rs1130233-AA/GA genotypes were associated with increased risk of developing cachexia in both cohorts (SELP: p = 0.011 and p = 0.045; AKT1: p = 0.004 and p = 0.019 for the first and second cohorts, respectively), while patients carrying AKT1-rs1130233-GG survived significantly longer (p = 0.002 and p = 0.004 for the first and second cohorts, respectively).
|
25238546 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Investigation of Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in type 2 diabetes mellitus.
|
17598012 |
2007 |